Alkemade, Joris A., Hawkins, Nichola J., Baraldi, Elena, Buddie, Alan G., Cockerton, Helen M., Corkley, Isabel, Fraaije, Bart A., Gaya, Ester, Gifford, Danna R., Hartig, Florian, and others. (2025) Learning from Fungicide Resistance: Evolutionary Insights to Guide RNAi-based Control of Fungal Crop Pathogens. Fungal Biology Reviews, 53 . Article Number 100443. ISSN 1749-4613. E-ISSN 1878-0253. (doi:10.1016/j.fbr.2025.100443) (KAR id:110920)
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Language: English 
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| Official URL: https://doi.org/10.1016/j.fbr.2025.100443 |
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Abstract
Crop protection against fungal pathogens is essential to prevent crop losses and maintain food security. Current crop protection relies heavily on chemical fungicides. However, rapid evolution of fungicide resistance, the constant appearance of new pathogens, and legislation against chemical pesticides due to concerns regarding their impact on human health and the environment, mean new crop protection strategies are urgently required. One elegant solution is double-stranded RNA-based crop protection, which aims to silence selected genes in the pathogen to reduce crop damage. This technology brings the promise of targeting specific genes, which could be chosen to maximise protection, minimize off-target effects and reduce the risk of resistance evolution. Here we discuss strategies for successful use of this novel technology based on lessons learned from fungicide resistance and recent discoveries in fungal evolution derived from genome-sequencing.
| Item Type: | Article |
|---|---|
| DOI/Identification number: | 10.1016/j.fbr.2025.100443 |
| Uncontrolled keywords: | RNAi Crop protection; Fungicide resistance; Fungal pathogens; Evolutionary genomics |
| Subjects: | S Agriculture > SB Plant culture |
| Institutional Unit: | Schools > School of Natural Sciences > Biosciences |
| Former Institutional Unit: |
There are no former institutional units.
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| Funders: | Organisations -1 not found. |
| Depositing User: | Helen Cockerton |
| Date Deposited: | 11 Aug 2025 11:28 UTC |
| Last Modified: | 01 Dec 2025 10:41 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/110920 (The current URI for this page, for reference purposes) |
University of Kent Author Information
Cockerton, Helen M..
| Creator's ORCID: |
 https://orcid.org/0000-0002-7375-1804
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