Towards the development of supramolecular self-associating amphiphiles as antibiofilm agents against Pseudomonas aeruginosa and Candida albicans biofilms

Hilton, Kira L.F., Steyn, Hendrik, luthuli, Kusa, Rice, Matthew Robert Edward, Streather, Bree, sweeney, esther, White, Lisa J., morgan, Findley, Rankin, Jennifer, baker, Jennifer, and others. (2025) Towards the development of supramolecular self-associating amphiphiles as antibiofilm agents against Pseudomonas aeruginosa and Candida albicans biofilms. Journal of Materials Chemistry B, 13 (27). pp. 8239-8251. ISSN 2050-750X. (doi:10.1039/D5TB00653H) (KAR id:110233)

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Official URL: https://doi.org/10.1039/D5TB00653H

Abstract

The rise of antimicrobial resistant (AMR) infection represents a growing threat to the global population and to economic health. The majority of antimicrobial innovations are developed against planktonic microorganisms, however those same microorganisms contained within a biofilm can become over 1000 times more resistant to antimicrobial (including antibiotic) agents. Supramolecular self-associating amphiphiles (SSAs) are a class of amphiphilic salts and related compounds that have shown the potential for development into antibiofilm agents. Within the scope of this work we present five structurally diverse SSAs. We characterise the self-associative properties of these SSAs in the solid state and in solution, before analysing the interactions of these agents with model synthetic membranes and determining their antibiofilm activity against WHO high/critical priority pathogens, Pseudomonas aeruginosa and Candida albicans. We also combine SSAs as 1:1 co-formulations and confirm the combination of SSA to inform both SSA phospholipid membrane interaction events and biological activity. Finally, we undertake a series of in vitro and in vivo DMPK experiments to verify the drug-like properties for these structurally diverse SSAs.

Item Type:	Article
DOI/Identification number:	10.1039/D5TB00653H
Subjects:	Q Science Q Science > QD Chemistry Q Science > QD Chemistry > QD431 Organic Chemistry- Biochemistry- Proteins, peptides, amino acids
Institutional Unit:	Schools > School of Natural Sciences Schools > School of Natural Sciences > Chemistry and Forensic Science
Former Institutional Unit:	There are no former institutional units.
Funders:	UK Research and Innovation (https://ror.org/001aqnf71)
Depositing User:	Jennifer Hiscock
Date Deposited:	08 Jun 2025 07:57 UTC
Last Modified:	22 Jul 2025 09:23 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/110233 (The current URI for this page, for reference purposes)

University of Kent Author Information

Rice, Matthew Robert Edward.

Creator's ORCID:
CReDIT Contributor Roles:

Hailey, Perry A..

Creator's ORCID:	https://orcid.org/0000-0002-8121-9674
CReDIT Contributor Roles:

Garrett, Michelle D..

Creator's ORCID:	https://orcid.org/0000-0002-3939-1673
CReDIT Contributor Roles:

Ortega-Roldan, Jose L..

Creator's ORCID:	https://orcid.org/0000-0002-6316-4390
CReDIT Contributor Roles:

Hiscock, Jennifer R..

Creator's ORCID:	https://orcid.org/0000-0002-1406-8802
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