Lonnberg, H., Stromberg, R., Williams, A. (2004) Compelling evidence for a stepwise mechanism of the alkaline cyclisation of uridine 3 '-phosphate esters. Organic & Biomolecular Chemistry, 2 (15). pp. 2165-2167. ISSN 1477-0520. (doi:10.1039/b406926a) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:11014)
| The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. | |
| Official URL: https://doi.org/10.1039/b406926a |
|
Abstract
A Bronsted graph with a convex break at pK(a) (Lg) = 12.58 provides compelling evidence for an intermediate in the alkaline cyclisation of uridine 3'-phosphate esters. The transient pentacoordinated oxyphosphorane dianion intermediate collapses to reactant and cyclic uridine 2', 3'-monophosphate faster than it can pseudo-rotate and isomerise to the 2'-isomer.
| Item Type: | Article |
|---|---|
| DOI/Identification number: | 10.1039/b406926a |
| Additional information: | 36 ROYAL SOC CHEMISTRY 841UP |
| Subjects: | Q Science |
| Institutional Unit: | Schools > School of Engineering, Mathematics and Physics > Physics and Astronomy |
| Former Institutional Unit: |
Divisions > Division of Natural Sciences > Physics and Astronomy
|
| Depositing User: | Maggie Francis |
| Date Deposited: | 25 Sep 2008 16:19 UTC |
| Last Modified: | 20 May 2025 09:30 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/11014 (The current URI for this page, for reference purposes) |
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