The current landscape of artificial intelligence in computational histopathology for cancer diagnosis

Artificial intelligence (AI) marks a frontier in histopathologic analysis shift towards the clinic, becoming a mainstream choice to interpret histological images. Surveying studies assessing AI applications in histopathology from 2013 to 2024, we review key methods (including supervised, unsupervised, weakly supervised and transfer learning) in deep learning-based pattern recognition in computational histopathology for diagnostic and prognostic purposes. Deep learning methods also showed utility in identifying a wide range of genetic mutations and standard pathology biomarkers from routine histology. This survey of 41 primary studies also encompasses key regions of AI applicability in histopathology in a multi-cancer review while marking prospects to introduce AI into the clinical setting with key examples including Swarm Learning and Data Fusion.