Relationship between Blastocystis infection and clinical outcomes: A scoping review protocol [version 1; peer review: 4 approved]

Blastocystis, a common protist in the human gastrointestinal tract, exhibits substantial genetic diversity and has been linked to varying clinical outcomes. However, its role in human health remains debated, with studies suggesting both commensal and pathogenic interactions. This scoping review aims to systematically map the existing evidence on the association between Blastocystis presence and human clinical outcomes. Herein, we present our proposed protocol, where, using systematic search methods, studies will be identified from multiple databases, focusing on diagnostic procedures, clinical outcomes, and treatment options. Findings will provide a comprehensive evidence map, highlighting knowledge gaps and guiding future research. The resulting data is intended to inform clinical and public health perspectives on Blastocystis and its potential implications for human health.