Bayesian Inference General Procedures for A Single-subject Test Study

Abnormality detection in the identification of a single-subject which deviates from the majority of the dataset that comes from a control group is a critical problem. A common approach is to assume that the control group can be characterised in terms of standard Normal statistics and the detection of single abnormal subject is in that context. But in many situations the control group can not be described in terms of Gaussian statistics and the use of standard statistics is inappropriate. This paper presents a Bayesian Inference General Procedures for A Single-Subject Test (BIGPAST), designed to mitigate the effects of skewness under the assumption that the dataset of control group comes from the skewed Student’s t distribution. BIGPAST operates under the null hypothesis that the single-subject follows the same distribution as the control group. We assess BIGPAST’s performance against other methods through a series of simulation studies. The results demonstrate that BIGPAST is robust against deviations from normality and outperforms the existing approaches in terms of accuracy. This is because BIGPAST can effectively reduce model misspecification errors under the skewed Student’s t assumption. We apply BIGPAST to a MEG dataset consisting of an individual with mild traumatic brain injury and an age and gender-matched control group, demonstrating its effectiveness in detecting abnormalities in the single-subject.