Mahajan, Ishika, Kadam, Amogh, McCann, Lucy, Ghose, Aruni, Wakeham, Katie, Dhillon, Navjot Singh, Stanway, Susannah, Boussios, Stergios, Banerjee, Soirindhri, Priyadarshini, Ashwini, and others. (2024) Early adoption of innovation in HPV prevention strategies: closing the gap in cervical cancer. Ecancermedicalscience, 18 . Article Number 1762. ISSN 1754-6605. (doi:10.3332/ecancer.2024.1762) (KAR id:107690)
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Official URL: https://doi.org/10.3332/ecancer.2024.1762 |
Abstract
Cervical cancer (CC) is one of the highest prevailing causes of female cancer-related mortality globally. A significant discrepancy in incidence has been noted between high and low-middle-income countries. The origins of CC have been accredited to the human papillomavirus (HPV) with serotypes 16 and 18 being the most prevalent. HPV vaccines, with 90%-97% efficacy, have proven safe and currently function as the primary prevention method. In addition, secondary prevention by timely screening can potentially increase the 5-year survival rate by >90%. High-precision HPV DNA testing has proven to be both highly sensitive and specific for early detection and is advocated by the WHO. Lack of public awareness, poor screening infrastructure and access to vaccines, socio-cultural concerns, along with economic, workforce-associated barriers and the presence of marginalised communities unable to access services have contributed to a continued high incidence. This article comprehensively analyses the efficacy, coverage, benefits and cost-effectiveness of CC vaccines and screening strategies including the transition from cytological screening to HPV self-sampling, while simultaneously exploring the real-world disparities in their feasibility. Furthermore, it calls for the implementation of population-based approaches that address the obstacles faced in approaching the WHO 2030 targets for CC elimination.
Item Type: | Article |
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DOI/Identification number: | 10.3332/ecancer.2024.1762 |
Uncontrolled keywords: | elimination, population health, HPV, secondary prevention, primary prevention, screening, cervical cancer, vaccine, Pap |
Subjects: | R Medicine |
Divisions: | Divisions > Division of Natural Sciences > Kent and Medway Medical School |
Funders: | University of Kent (https://ror.org/00xkeyj56) |
SWORD Depositor: | JISC Publications Router |
Depositing User: | JISC Publications Router |
Date Deposited: | 06 Nov 2024 15:04 UTC |
Last Modified: | 08 Nov 2024 11:55 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/107690 (The current URI for this page, for reference purposes) |
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