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Genetic diversity in the Orenburg goat breed revealed by single-nucleotide polymorphism (SNP) analysis: Initial steps in saving a threatened population

Deniskova, Tatiana E., Dotsev, Arsen V., Abdelmanova, Alexandra S., Petrov, Sergey N., Frolov, Alexei N., Platonov, Stanislav A., Gladyr, Elena A., Gusev, Igor V., Selionova, Marina I., Rodionov, Andrey N., and others. (2024) Genetic diversity in the Orenburg goat breed revealed by single-nucleotide polymorphism (SNP) analysis: Initial steps in saving a threatened population. Genes, 15 (11). Article Number 1375. E-ISSN 2073-4425. (doi:10.3390/genes15111375) (KAR id:107608)

Abstract

Background/Objectives: Orenburg goats are renowned for their soft down that acts as a substrate for warm clothing, particularly shawls that have an international reputation. As with many local livestock breeds, however, the Orenburg is presently at risk of extinction, an issue that can be addressed by assessing population genetic diversity and, thereafter, encouraging as much outbreeding as possible. Using single-nucleotide polymorphism (SNP)-based data, therefore, we analyzed the genetic diversity and population structure of modern Orenburg goats using samples collected from an expedition to Orenburg Oblast in 2024. Methods: We applied the Goat SNP50 BeadChip (Illumina, San Diego, CA, USA) for the genotyping of Orenburg goats from modern and archived populations. SNP genotypes of three Orenburg populations sampled in 2017 and 2019, Altai Mountain, Altai White, and Soviet Mohair breeds, were added to the dataset. Results: Principal component analysis and network and admixture analyses demonstrated that the genetic background inherent to the archived group of Orenburg goats was maintained in all modern populations. Values of genetic diversity indicators in modern populations were compatible with those obtained in comparison groups. Runs of homozygosity (ROH) were found in all the Orenburg goat populations (with a mean ROH length of 72.6–108.9 Mb and mean ROH number of 28–36). Genomic inbreeding based on ROH was low in all the Orenburg populations (FROH = 0.03–0.045). Conclusions: We showed that the ancestral background is retained in present-day Orenburg goats sampled in 2024. We provide the genetic basis through which certain breeder animals may be selected and bred traditionally or ex situ through a conservation program of gamete preservation.

Item Type: Article
DOI/Identification number: 10.3390/genes15111375
Uncontrolled keywords: Orenburg goats; single-nucleotide polymorphism (SNP); local breeds; population structure; genetic diversity
Subjects: Q Science > QH Natural history > QH426 Genetics
Q Science > QH Natural history > QH75 Conservation (Biology)
S Agriculture > SF Animal culture
Divisions: Divisions > Division of Natural Sciences > Centre for Interdisciplinary Studies of Reproduction
Divisions > Division of Natural Sciences > Biosciences
Signature Themes: Food Systems, Natural Resources and Environment
Depositing User: Mike Romanov
Date Deposited: 25 Oct 2024 11:23 UTC
Last Modified: 06 Feb 2025 12:03 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/107608 (The current URI for this page, for reference purposes)

University of Kent Author Information

Griffin, Darren K..

Creator's ORCID: https://orcid.org/0000-0001-7595-3226
CReDIT Contributor Roles: Supervision, Writing - review and editing

Romanov, Michael N..

Creator's ORCID: https://orcid.org/0000-0003-3584-4644
CReDIT Contributor Roles: Writing - review and editing
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