Feasibility and safety of a home-based electroencephalogram neurofeedback intervention to reduce chronic neuropathic pain: a cohort clinical trial.

Objective: To evaluate the feasibility, safety, and potential health benefits of an 8- week home-based neurofeedback intervention. Design: Single-group preliminary study. Setting: Community-based.

Participants: Nine community dwelling adults with chronic neuropathic pain, 6 women and 3 men, with an average age of 51.9 years (range, 19-78 years) and with a 7-day average minimum pain score of 4 of 10 on the visual analog pain scale. Interventions: A minimum of 5 neurofeedback sessions per week (40min/session) for 8 consecu tive weeks was undertaken with a 12-week follow-up baseline electroencephalography recording period.

Main Outcome Measures: Primary feasibility outcomes: accessibility, tolerability, safety (adverse events and resolution), and human and information technology (IT) resources required. Second ary outcomes: pain, sensitization, catastrophization, anxiety, depression, sleep, health-related quality of life, electroencephalographic activity, and simple participant feedback.

Results: Of the 23 people screened, 11 were eligible for recruitment. One withdrew and another completed insufficient sessions for analysis, which resulted in 9 datasets analyzed. Three partici pants withdrew from the follow-up baselines, leaving 6 who completed the entire trial protocol. Thirteen adverse events were recorded and resolved: 1 was treatment-related, 4 were equip ment-related, and 8 were administrative-related (eg, courier communication issues). The human and IT resources necessary for trial implementation were identified. There were also significant improvements in pain levels, depression, and anxiety. Six of 9 participants perceived minimal improvement or no change in symptoms after the trial, and 5 of 9 participants were satisfied with the treatment received.

Conclusions: It is feasible and safe to conduct a home-based trial of a neurofeedback interven tion for people with chronic neuropathic pain, when the human and IT resources are provided and relevant governance processes are followed. Improvements in secondary outcomes merit investigation with a randomized controlled trial.