Serrano-Sanchez, Angela, Rice, Matthew Robert Edward, Cassar, Joseph, White, Lisa J., Popoola, Precious I. A., Thompson, Gary S., Hiscock, Jennifer R., Ortega-Roldan, Jose L. (2024) A solution NMR methodology enabling the elucidation of small molecule phospholipid membrane adhesion and passive permeation parameters. Chemical Communications, 60 (79). pp. 11160-11163. ISSN 1359-7345. E-ISSN 1364-548X. (doi:10.1039/d4cc01515k) (KAR id:107357)
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Language: English 
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| Official URL: https://doi.org/10.1039/d4cc01515k |
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Abstract
Quantifying small molecule uptake across a biological membrane of a target cell is crucial for the development of efficacious and selective drugs. However, current methods to obtaining such data are not trivial. Herein, we present an accessible, higher-throughput (20 minutes), 1 H NMR spectroscopy assay, which enables the quantification of small molecule phospholipid passive membrane permeation and membrane adhesion parameters.
| Item Type: | Article |
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| DOI/Identification number: | 10.1039/d4cc01515k |
| Additional information: | For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. |
| Subjects: | Q Science |
| Institutional Unit: |
Schools > School of Natural Sciences > Biosciences Schools > School of Natural Sciences > Chemistry and Forensic Science |
| Former Institutional Unit: |
Divisions > Division of Natural Sciences > Biosciences Divisions > Division of Natural Sciences > Chemistry and Forensics
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| Funders: |
UK Research and Innovation (https://ror.org/001aqnf71)
Royal Society (https://ror.org/03wnrjx87) |
| Depositing User: | Angela Serrano Sanchez |
| Date Deposited: | 26 Sep 2024 11:41 UTC |
| Last Modified: | 22 Jul 2025 09:21 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/107357 (The current URI for this page, for reference purposes) |
University of Kent Author Information
Serrano-Sanchez, Angela.
| Creator's ORCID: | |
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| CReDIT Contributor Roles: |
Rice, Matthew Robert Edward.
| Creator's ORCID: | |
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| CReDIT Contributor Roles: |
Cassar, Joseph.
| Creator's ORCID: | |
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| CReDIT Contributor Roles: |
Popoola, Precious I. A..
| Creator's ORCID: |
 https://orcid.org/0000-0002-3961-3782
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| CReDIT Contributor Roles: |
Thompson, Gary S..
| Creator's ORCID: |
https://orcid.org/0000-0001-9399-7636
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| CReDIT Contributor Roles: |
Hiscock, Jennifer R..
| Creator's ORCID: |
https://orcid.org/0000-0002-1406-8802
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| CReDIT Contributor Roles: |
Ortega-Roldan, Jose L..
| Creator's ORCID: |
https://orcid.org/0000-0002-6316-4390
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| CReDIT Contributor Roles: |
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