A solution NMR methodology enabling the elucidation of small molecule phospholipid membrane adhesion and passive permeation parameters

Serrano-Sanchez, Angela, Rice, Matthew Robert Edward, Cassar, Joseph, White, Lisa J., Popoola, Precious I. A., Thompson, Gary S., Hiscock, Jennifer R., Ortega-Roldan, Jose L. (2024) A solution NMR methodology enabling the elucidation of small molecule phospholipid membrane adhesion and passive permeation parameters. Chemical Communications, 60 (79). pp. 11160-11163. ISSN 1359-7345. E-ISSN 1364-548X. (doi:10.1039/d4cc01515k) (KAR id:107357)

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Official URL: https://doi.org/10.1039/d4cc01515k

Abstract

Quantifying small molecule uptake across a biological membrane of a target cell is crucial for the development of efficacious and selective drugs. However, current methods to obtaining such data are not trivial. Herein, we present an accessible, higher-throughput (20 minutes), 1 H NMR spectroscopy assay, which enables the quantification of small molecule phospholipid passive membrane permeation and membrane adhesion parameters.

Item Type:	Article
DOI/Identification number:	10.1039/d4cc01515k
Additional information:	For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.
Subjects:	Q Science
Divisions:	Divisions > Division of Natural Sciences > Biosciences Divisions > Division of Natural Sciences > Chemistry and Forensics
Funders:	UK Research and Innovation (https://ror.org/001aqnf71) Royal Society (https://ror.org/03wnrjx87)
Depositing User:	Angela Serrano Sanchez
Date Deposited:	26 Sep 2024 11:41 UTC
Last Modified:	05 Nov 2024 13:13 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/107357 (The current URI for this page, for reference purposes)

University of Kent Author Information

Serrano-Sanchez, Angela.

Creator's ORCID:
CReDIT Contributor Roles:

Rice, Matthew Robert Edward.

Creator's ORCID:
CReDIT Contributor Roles:

Cassar, Joseph.

Creator's ORCID:
CReDIT Contributor Roles:

Popoola, Precious I. A..

Creator's ORCID:	https://orcid.org/0000-0002-3961-3782
CReDIT Contributor Roles:

Thompson, Gary S..

Creator's ORCID:	https://orcid.org/0000-0001-9399-7636
CReDIT Contributor Roles:

Hiscock, Jennifer R..

Creator's ORCID:	https://orcid.org/0000-0002-1406-8802
CReDIT Contributor Roles:

Ortega-Roldan, Jose L..

Creator's ORCID:	https://orcid.org/0000-0002-6316-4390
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