Serrano-Sanchez, Angela, Rice, Matthew Robert Edward, Cassar, Joseph, White, Lisa J., Popoola, Precious I. A., Thompson, Gary S., Hiscock, Jennifer R., Ortega-Roldan, Jose L. (2024) A solution NMR methodology enabling the elucidation of small molecule phospholipid membrane adhesion and passive permeation parameters. Chemical Communications, . ISSN 1359-7345. (doi:10.1039/d4cc01515k) (KAR id:107357)
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Official URL: https://doi.org/10.1039/d4cc01515k |
Abstract
Quantifying small molecule uptake across a biological membrane of a target cell is crucial for the development of efficacious and selective drugs. However, current methods to obtaining such data are not trivial. Herein, we present an accessible, higher-throughput (20 minutes), 1 H NMR spectroscopy assay, which enables the quantification of small molecule phospholipid passive membrane permeation and membrane adhesion parameters.
Item Type: | Article |
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DOI/Identification number: | 10.1039/d4cc01515k |
Subjects: | Q Science |
Divisions: |
Divisions > Division of Natural Sciences > Biosciences Divisions > Division of Natural Sciences > Chemistry and Forensics |
Funders: |
UK Research and Innovation (https://ror.org/001aqnf71)
Royal Society (https://ror.org/03wnrjx87) |
Depositing User: | Joanne Picton |
Date Deposited: | 26 Sep 2024 11:41 UTC |
Last Modified: | 26 Sep 2024 11:41 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/107357 (The current URI for this page, for reference purposes) |
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