Uddin, Md Jasim, Economidou, Sophia N., Guiraud, Léa, Kazi, Mohsin, Alanazi, Fars K, Douroumis, Dennis (2024) Monoclonal Antibody Delivery Using 3D Printed Biobased Hollow μNe3dle Arrays for the Treatment of Osteoporosis. Molecular pharmaceutics, . ISSN 1543-8384. E-ISSN 1543-8392. (doi:10.1021/acs.molpharmaceut.4c00379) (KAR id:106951)
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Official URL: https://doi.org/10.1021/acs.molpharmaceut.4c00379 |
Abstract
Transdermal microneedles have demonstrated promising potential as an alternative to typical drug administration routes for the treatment of various diseases. As microneedles offer lower administration burden with enhanced patient adherence and reduced ecological footprint, there is a need for further exploitation of microneedle devices. One of the main objectives of this work was to initially develop an innovative biobased photocurable resin with high biobased carbon content comprising isobornyl acrylate (IBA) and pentaerythritol tetraacrylate blends (50:50 wt/wt). The optimization of the printing and curing process resulted in μNe3dle arrays with durable mechanical properties and piercing capacity. Another objective of the work was to employ the 3D printed hollow μNe3dles for the treatment of osteoporosis in vivo. The 3D printed μNe3dle arrays were used to administer denosumab (Dmab), a monoclonal antibody, to osteoporotic mice, and the serum concentrations of critical bone minerals were monitored for six months to assess recovery. It was found that the Dmab administered by the 3D printed μNe3dles showed fast in vitro rates and induced an enhanced therapeutic effect in restoring bone-related minerals compared to subcutaneous injections. The findings of this study introduce a novel green approach with a low ecological footprint for 3D printing of biobased μNe3dles, which can be tailored to improve clinical outcomes and patient compliance for chronic diseases.
Item Type: | Article |
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DOI/Identification number: | 10.1021/acs.molpharmaceut.4c00379 |
Uncontrolled keywords: | microneedles, 3D printing, digital, light Processing, osteoporosis, monoclonal Antibody |
Subjects: |
R Medicine R Medicine > RM Therapeutics. Pharmacology |
Divisions: | Divisions > Division of Natural Sciences > Medway School of Pharmacy |
Funders: | University of Kent (https://ror.org/00xkeyj56) |
SWORD Depositor: | JISC Publications Router |
Depositing User: | JISC Publications Router |
Date Deposited: | 21 Aug 2024 10:35 UTC |
Last Modified: | 22 Aug 2024 14:18 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/106951 (The current URI for this page, for reference purposes) |
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