Ihalainen, Riku, Annen, Jitka, Gosseries, Olivia, Cardone, Paolo, Panda, Rajanikant, Martial, Charlotte, Thibaut, Aurore, Laureys, Steven, Chennu, Srivas (2024) Lateral frontoparietal effective connectivity differentiates and predicts state of consciousness in a cohort of patients with traumatic disorders of consciousness. PLOS ONE, 19 (7). Article Number e0298110. ISSN 1932-6203. (doi:10.1371/journal.pone.0298110) (KAR id:106498)
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Official URL: https://doi.org/10.1371/journal.pone.0298110 |
Abstract
Neuroimaging studies have suggested an important role for the default mode network (DMN) in disorders of consciousness (DoC). However, the extent to which DMN connectivity can discriminate DoC states–unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS)–is less evident. Particularly, it is unclear whether effective DMN connectivity, as measured indirectly with dynamic causal modelling (DCM) of resting EEG can disentangle UWS from healthy controls and from patients considered conscious (MCS+). Crucially, this extends to UWS patients with potentially “covert” awareness (minimally conscious star, MCS*) indexed by voluntary brain activity in conjunction with partially preserved frontoparietal metabolism as measured with positron emission tomography (PET+ diagnosis; in contrast to PET- diagnosis with complete frontoparietal hypometabolism). Here, we address this gap by using DCM of EEG data acquired from patients with traumatic brain injury in 11 UWS (6 PET- and 5 PET+) and in 12 MCS+ (11 PET+ and 1 PET-), alongside with 11 healthy controls. We provide evidence for a key difference in left frontoparietal connectivity when contrasting UWS PET- with MCS+ patients and healthy controls. Next, in a leave-one-subject-out cross-validation, we tested the classification performance of the DCM models demonstrating that connectivity between medial prefrontal and left parietal sources reliably discriminates UWS PET- from MCS+ patients and controls. Finally, we illustrate that these models generalize to an unseen dataset: models trained to discriminate UWS PET- from MCS+ and controls, classify MCS* patients as conscious subjects with high posterior probability (pp > .92). These results identify specific alterations in the DMN after severe brain injury and highlight the clinical utility of EEG-based effective connectivity for identifying patients with potential covert awareness.
Item Type: | Article |
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DOI/Identification number: | 10.1371/journal.pone.0298110 |
Subjects: | Q Science > QA Mathematics (inc Computing science) |
Divisions: | Divisions > Division of Computing, Engineering and Mathematical Sciences > School of Computing |
Funders: | Engineering and Physical Sciences Research Council (https://ror.org/0439y7842) |
SWORD Depositor: | JISC Publications Router |
Depositing User: | JISC Publications Router |
Date Deposited: | 09 Jul 2024 08:15 UTC |
Last Modified: | 10 Jul 2024 11:04 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/106498 (The current URI for this page, for reference purposes) |
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