Marchi, Serena, Piccini, Giulia, Cantaloni, Paolo, Guerrini, Noemi, Zannella, Roberta, Coluccio, Rosa, Benincasa, Linda, Solfanelli, Niccolò, Remarque, Edmond J., Viviani, Simonetta, and others. (2024) Evaluation of monkeypox‐ and vaccinia‐virus neutralizing antibodies before and after smallpox vaccination: A sero‐epidemiological study. Journal of Medical Virology, 96 (6). Article Number e29728. ISSN 0146-6615. E-ISSN 1096-9071. (doi:10.1002/jmv.29728) (KAR id:106306)
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Language: English 
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| Official URL: https://doi.org/10.1002/jmv.29728 |
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Abstract
Since May 2022, several countries outside of Africa experienced multiple clusters of monkeypox virus (MPXV)-associated disease. In the present study, anti-MPXV and anti-vaccinia virus (VACV) neutralizing antibody responses were evaluated in two cohorts of subjects from the general Italian population (one half born before the WHO-recommended end of smallpox vaccination in 1980, the other half born after). Higher titers (either against MPXV or VACV) were observed in the cohort of individuals born before the interruption of VACV vaccination. An association between VACV and MPXV antibody levels was observed, suggesting that the smallpox vaccination may confer some degree of cross-protection against MPXV infection. Results from this study highlight low levels of immunity toward the assessed Orthopoxviruses, especially in young adults, advocating the introduction of a VACV- or MPXV-specific vaccine in case of resurgence of monkeypox disease outbreaks.
| Item Type: | Article |
|---|---|
| DOI/Identification number: | 10.1002/jmv.29728 |
| Uncontrolled keywords: | humoral immunity; monkeypox virus; neutralization; vaccinia virus |
| Subjects: | Q Science > QR Microbiology > QR355 Virology |
| Divisions: | Divisions > Division of Natural Sciences > Medway School of Pharmacy |
| Funders: | University of Kent (https://ror.org/00xkeyj56) |
| Depositing User: | Nigel Temperton |
| Date Deposited: | 17 Jun 2024 21:52 UTC |
| Last Modified: | 26 Jun 2024 02:48 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/106306 (The current URI for this page, for reference purposes) |
University of Kent Author Information
Temperton, Nigel.
| Creator's ORCID: |
 https://orcid.org/0000-0002-7978-3815
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