Steponenaite, Aiste, Lalic, Tatjana, Atkinson, Lynsey, Neil, Tanday, Brown, Lorna, Mathie, Alistair, Cader, Zameel M., Lall, Gurprit S. (2024) TASK-3, two-pore potassium channels, contribute to circadian rhythms in the electrical properties of the suprachiasmatic nucleus and play a role in driving stable behavioural photic entrainment. Chronobiology international, 41 (6). pp. 802-806. ISSN 0742-0528. E-ISSN 1525-6073. (doi:10.1080/07420528.2024.2351515) (KAR id:106024)
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Official URL: https://doi.org/10.1080/07420528.2024.2351515 |
Abstract
Stable and entrainable physiological circadian rhythms are crucial for overall health and well-being. The suprachiasmatic nucleus (SCN), the primary circadian pacemaker in mammals, consists of diverse neuron types that collectively generate a circadian profile of electrical activity. However, the mechanisms underlying the regulation of endogenous neuronal excitability in the SCN remain unclear. Two-pore domain potassium channels (K2P), including TASK-3, are known to play a significant role in maintaining SCN diurnal homeostasis by inhibiting neuronal activity at night. In this study, we investigated the role of TASK-3 in SCN circadian neuronal regulation and behavioural photoentrainment using a TASK-3 global knockout mouse model. Our findings demonstrate the importance of TASK-3 in maintaining SCN hyperpolarization during the night and establishing SCN sensitivity to glutamate. Specifically, we observed that TASK-3 knockout mice lacked diurnal variation in resting membrane potential and exhibited altered glutamate sensitivity both in vivo and in vitro. Interestingly, despite these changes, the mice lacking TASK-3 were still able to maintain relatively normal circadian behaviour.
Item Type: | Article |
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DOI/Identification number: | 10.1080/07420528.2024.2351515 |
Uncontrolled keywords: | SCN, TASK-3, background two-pore domain potassium channels (K2P), entrainment, resting membrane potential, circadian rhythms |
Subjects: | Q Science > Q Science (General) |
Divisions: | Divisions > Division of Natural Sciences > Medway School of Pharmacy |
Funders: | Royal Society (https://ror.org/03wnrjx87) |
Depositing User: | Aiste Steponenaite |
Date Deposited: | 20 May 2024 10:55 UTC |
Last Modified: | 01 Jul 2024 13:50 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/106024 (The current URI for this page, for reference purposes) |
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