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TASK-3, two-pore potassium channels, contribute to circadian rhythms in the electrical properties of the suprachiasmatic nucleus and play a role in driving stable behavioural photic entrainment

Steponenaite, Aiste, Lalic, Tatjana, Atkinson, Lynsey, Neil, Tanday, Brown, Lorna, Mathie, Alistair, Cader, Zameel M., Lall, Gurprit S. (2024) TASK-3, two-pore potassium channels, contribute to circadian rhythms in the electrical properties of the suprachiasmatic nucleus and play a role in driving stable behavioural photic entrainment. Chronobiology international, . pp. 1-15. ISSN 0742-0528. E-ISSN 1525-6073. (doi:10.1080/07420528.2024.2351515) (KAR id:106024)

Abstract

Stable and entrainable physiological circadian rhythms are crucial for overall health and well-being. The suprachiasmatic nucleus (SCN), the primary circadian pacemaker in mammals, consists of diverse neuron types that collectively generate a circadian profile of electrical activity. However, the mechanisms underlying the regulation of endogenous neuronal excitability in the SCN remain unclear. Two-pore domain potassium channels (K2P), including TASK-3, are known to play a significant role in maintaining SCN diurnal homeostasis by inhibiting neuronal activity at night. In this study, we investigated the role of TASK-3 in SCN circadian neuronal regulation and behavioural photoentrainment using a TASK-3 global knockout mouse model. Our findings demonstrate the importance of TASK-3 in maintaining SCN hyperpolarization during the night and establishing SCN sensitivity to glutamate. Specifically, we observed that TASK-3 knockout mice lacked diurnal variation in resting membrane potential and exhibited altered glutamate sensitivity both in vivo and in vitro. Interestingly, despite these changes, the mice lacking TASK-3 were still able to maintain relatively normal circadian behaviour.

Item Type: Article
DOI/Identification number: 10.1080/07420528.2024.2351515
Uncontrolled keywords: SCN, TASK-3, background two-pore domain potassium channels (K2P), entrainment, resting membrane potential, circadian rhythms
Subjects: Q Science > Q Science (General)
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Funders: Royal Society (https://ror.org/03wnrjx87)
Depositing User: Aiste Steponenaite
Date Deposited: 20 May 2024 10:55 UTC
Last Modified: 07 Jun 2024 11:44 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/106024 (The current URI for this page, for reference purposes)

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