Ghose, Aruni, Lapitan, Patricia, Apte, Vedika, Ghosh, Adheesh, Kandala, Abhinav, Basu, Sreejana, Parkes, Jo, Shinde, Sayali D, Boussios, Stergios, Sharma, Anand, and others. (2024) Antibody Drug Conjugates in Urological Cancers: A Review of the Current Landscape. Current Oncology Reports, . ISSN 1523-3790. (doi:10.1007/s11912-024-01524-7) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:105861)
| The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication) | |
| Official URL: https://doi.org/10.1007/s11912-024-01524-7 |
Abstract
Our review delves into the progress across urological malignancies and discusses ongoing challenges and future directions in antibody-drug conjugate (ADC) development, emphasising their transformative potential in cancer care. ADCs have advanced from hematologic to solid tumours, notably in breast cancer, and are now pivotal in metastatic urological cancers as both monotherapies and in combination regimens, underscored by the FDA's approval of enfortumab vedotin and sacituzumab govitecan for metastatic urothelial cancer. Progress in metastatic prostate cancer, particularly with ADCs targeting PSMA and STEAP1, is noteworthy, although renal cell cancer presents ongoing challenges. There is a continual search for agents in the metastatic, relapsed testicular cancer landscape. ADCs have emerged as a pivotal innovation in oncology, blending targeted antibody therapy with potent cytotoxic drugs, significantly advancing treatment options for urological malignancies.
| Item Type: | Article |
|---|---|
| DOI/Identification number: | 10.1007/s11912-024-01524-7 |
| Uncontrolled keywords: | Prostate, Testicular, Cancer, Urology, Urothelial, Antibody drug conjugate, Renal, Chemotherapy |
| Subjects: | R Medicine |
| Divisions: | Divisions > Division of Natural Sciences > Kent and Medway Medical School |
| SWORD Depositor: | JISC Publications Router |
| Depositing User: | JISC Publications Router |
| Date Deposited: | 10 May 2024 15:16 UTC |
| Last Modified: | 13 May 2024 10:31 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/105861 (The current URI for this page, for reference purposes) |
University of Kent Author Information
Boussios, Stergios.
| Creator's ORCID: |
 https://orcid.org/0000-0002-2512-6131
|
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