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lncRNA Biomarkers of Glioblastoma Multiforme

Pokorná, Markéta, Černá, Marie, Boussios, Stergios, Ovsepian, Saak V., O’Leary, Valerie Bríd (2024) lncRNA Biomarkers of Glioblastoma Multiforme. Biomedicines, 12 (5). Article Number 932. E-ISSN 2227-9059. (doi:10.3390/biomedicines12050932) (KAR id:105811)

Abstract

Long noncoding RNAs (lncRNAs) are RNA molecules of 200 nucleotides or more in length that are not translated into proteins. Their expression is tissue-specific, with the vast majority involved in the regulation of cellular processes and functions. Many human diseases, including cancer, have been shown to be associated with deregulated lncRNAs, rendering them potential therapeutic targets and biomarkers for differential diagnosis. The expression of lncRNAs in the nervous system varies in different cell types, implicated in mechanisms of neurons and glia, with effects on the development and functioning of the brain. Reports have also shown a link between changes in lncRNA molecules and the etiopathogenesis of brain neoplasia, including glioblastoma multiforme (GBM). GBM is an aggressive variant of brain cancer with an unfavourable prognosis and a median survival of 14–16 months. It is considered a brain-specific disease with the highly invasive malignant cells spreading throughout the neural tissue, impeding the complete resection, and leading to post-surgery recurrences, which are the prime cause of mortality. The early diagnosis of GBM could improve the treatment and extend survival, with the lncRNA profiling of biological fluids promising the detection of neoplastic changes at their initial stages and more effective therapeutic interventions. This review presents a systematic overview of GBM-associated deregulation of lncRNAs with a focus on lncRNA fingerprints in patients’ blood.

Item Type: Article
DOI/Identification number: 10.3390/biomedicines12050932
Uncontrolled keywords: lncRNA; noncoding RNA; glioblastoma multiforme; glioma; plasma; serum; blood; biomarker; liquid biopsy; AC016405.3; ADAMTs9-AS2; AGAP2-AS1; AHIF; ANRIL; lncRNA-ATB; CASC2; CASC7; CASC9; CCND2-AS1; CRNDE; DCST1-AS1; DGCR5; DLEU1-AS1; ECONEXIN; LINC00461; FAM66C; GAS5; H19; HMMR-AS1; HOTAIR; HOTAIRM1; HOXA-AS2; HOXB13-1; HOTTIP; HULC; KTN1-AS1; LINC00467; LINC00565; LINC00641; LINC01393; LINC01426; LINC01446; LINC01494; LINC01503; LINC01711; LINC02283; LINC-ROR; lnc-TALC; MAFG-DT; MALAT1; MATN1-AS1; MDC1-AS; MEG3; MIAT; MIR210HG; MNX1-AS1; NCK1-AS1; NEAT1; PART1; PARTICLE; PCAT1; PCA1; PVT1; RBPMS-AS1; RPSAP52; RUNX1-IT1; SAMMSON; SOX2-OT; TALNEC2; TP73-AS1; TSLC1-AS1; TUSC7; TUG1; TUNAR; UCA1; XIST; ZEB1-AS1; ZBED3-AS1
Subjects: R Medicine
Divisions: Divisions > Division of Natural Sciences > Kent and Medway Medical School
Funders: Charles University (https://ror.org/024d6js02)
SWORD Depositor: JISC Publications Router
Depositing User: JISC Publications Router
Date Deposited: 03 May 2024 13:28 UTC
Last Modified: 07 May 2024 14:30 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/105811 (The current URI for this page, for reference purposes)

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