Mexiletine: Antiarrhythmic mechanisms, emerging clinical applications and mortality

Olleik, Farah, Kamareddine, Mohammed Hussein, Spears, Jenna, Tse, Gary, Liu, Tong, Yan, Gan‐Xin (2023) Mexiletine: Antiarrhythmic mechanisms, emerging clinical applications and mortality. Pacing and Clinical Electrophysiology, 46 (11). pp. 1348-1356. ISSN 1540-8159. (doi:10.1111/pace.14846) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:104147)

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Official URL: https://doi.org/10.1111/pace.14846

Abstract

Mexiletine, a class Ib antiarrhythmic drug, exhibits its major antiarrhythmic effect via inhibition of the fast and late Na+ currents in myocardial tissues that are dependent on the opening of Na+ channels for their excitation. Through a comprehensive examination of mexiletine's therapeutic benefits and potential risks, we aim to provide valuable insights that reinforce its role as a vital therapeutic option for patients with ventricular arrhythmias, long QT syndrome, and other heart rhythm disorders. This review will highlight the current understandings of the antiarrhythmic effects and rationales for recent off‐label use and address the mortality and proarrhythmic effects of mexiletine utilizing published basic and clinical studies over the past five decades.

Item Type:	Article
DOI/Identification number:	10.1111/pace.14846
Uncontrolled keywords:	Cardiology and Cardiovascular Medicine, General Medicine
Subjects:	R Medicine
Divisions:	Divisions > Division of Natural Sciences > Kent and Medway Medical School
SWORD Depositor:	JISC Publications Router
Depositing User:	JISC Publications Router
Date Deposited:	22 Mar 2024 15:06 UTC
Last Modified:	22 Mar 2024 15:06 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/104147 (The current URI for this page, for reference purposes)

University of Kent Author Information

Tse, Gary.

Creator's ORCID:	https://orcid.org/0000-0001-5510-1253
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