Phospholipid headgroup composition modulates the molecular interactions and antimicrobial effects of sulfobetaine zwitterionic detergents against the “ESKAPE” pathogen Pseudomonas aeruginosa

Hilton, Kira, Tolley, Howard, Ortega-Roldan, Jose L., Thompson, Gary S., Sutton, Prof. Mark, Hind, Charlotte K., Hiscock, Jennifer R. (2023) Phospholipid headgroup composition modulates the molecular interactions and antimicrobial effects of sulfobetaine zwitterionic detergents against the “ESKAPE” pathogen Pseudomonas aeruginosa. Chemical Communications, 59 (70). pp. 10504-10507. ISSN 1359-7345. E-ISSN 1364-548X. (doi:10.1039/D3CC02320F) (KAR id:102336)

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Official URL: https://doi.org/10.1039/D3CC02320F

Abstract

We determine the efficacy for three known structurally related, membrane active detergents against multidrug resistant and wild type strains of Pseudomonas aeruginosa. Accessible solution state NMR experiments are used to quantify phospholipid headgroup composition of the microbial membranes and to gain molecular level insight into antimicrobial mode of action.

Item Type:	Article
DOI/Identification number:	10.1039/D3CC02320F
Additional information:	For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.
Uncontrolled keywords:	Materials Chemistry, Metals and Alloys, Surfaces, Coatings and Films, General Chemistry, Ceramics and Composites, Electronic, Optical and Magnetic Materials, Catalysis
Subjects:	Q Science Q Science > QD Chemistry > QD431 Organic Chemistry- Biochemistry- Proteins, peptides, amino acids
Divisions:	Divisions > Division of Natural Sciences > Chemistry and Forensics
Funders:	UK Research and Innovation (https://ror.org/001aqnf71) UK Health Security Agency (https://ror.org/018h10037)
Depositing User:	Jennifer Hiscock
Date Deposited:	04 Aug 2023 13:24 UTC
Last Modified:	08 Jan 2024 14:38 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/102336 (The current URI for this page, for reference purposes)

University of Kent Author Information

Hilton, Kira.

Creator's ORCID:
CReDIT Contributor Roles:

Ortega-Roldan, Jose L..

Creator's ORCID:	https://orcid.org/0000-0002-6316-4390
CReDIT Contributor Roles:

Thompson, Gary S..

Creator's ORCID:	https://orcid.org/0000-0001-9399-7636
CReDIT Contributor Roles:

Hiscock, Jennifer R..

Creator's ORCID:	https://orcid.org/0000-0002-1406-8802
CReDIT Contributor Roles:

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