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Association between serum uric acid and prostate cancer mortality in androgen deprivation therapy: A population‐based cohort study

Lee, Yan Hiu Athena, Chan, Jeffrey Shi Kai, Leung, Chi Ho, Hui, Jeremy Man Ho, Dee, Edward Christopher, Ng, Kenrick, Liu, Kang, Liu, Tong, Tse, Gary, Ng, Chi Fai and others. (2023) Association between serum uric acid and prostate cancer mortality in androgen deprivation therapy: A population‐based cohort study. Cancer Medicine, 12 (16). pp. 17056-17060. ISSN 2045-7634. E-ISSN 2045-7634. (doi:10.1002/cam4.6344) (KAR id:102109)

Abstract

Objective: This population‐based study examined the association between baseline uric acid (UA) and prostate cancer (PCa)‐related mortality amongst PCa patients receiving androgen deprivation therapy (ADT).

Methods: Adults with PCa who received ADT in Hong Kong between December 1999 and March 2021 were identified. Patients with missing baseline UA were excluded. Patients were followed up until September 2021. The outcome was PCa‐related mortality.

Results: Altogether, 4126 patients (median follow‐up 3.1[interquartile range 1.4–6.0] years) were included. A J‐shaped association was observed between baseline UA level and PCa‐related mortality risk, with a direct association in those with mean(0.401 mmol/L) or above‐mean baseline UA levels (hazard ratio (HR) per standard deviation‐increase 1.35 [95% confidence interval 1.21,1.51], p < 0.001), and an inverse association in those with below‐mean baseline UA levels (HR 0.78[0.67,0.92], p = 0.003). The former remained significant on competing risk regression, but not the latter.

Conclusions: A J‐shaped relationship between baseline UA level and PCa‐related mortality risk was identified. This study was mainly limited by potential unmeasured and residual confounders. Further validation studies are warranted.

Item Type: Article
DOI/Identification number: 10.1002/cam4.6344
Uncontrolled keywords: hormone therapy, epidemiology, prognostic factor, prostate cancer, clinical cancer research
Subjects: R Medicine
Divisions: Divisions > Division of Natural Sciences > Kent and Medway Medical School
SWORD Depositor: JISC Publications Router
Depositing User: JISC Publications Router
Date Deposited: 19 Jul 2023 08:27 UTC
Last Modified: 05 Nov 2024 13:08 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/102109 (The current URI for this page, for reference purposes)

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