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Long‐term prognostic impact of cardiovascular comorbidities in patients with prostate cancer receiving androgen deprivation therapy: A population‐based competing risk analysis

Chan, Jeffrey Shi Kai, Lee, Yan Hiu Athena, Hui, Jeremy Man Ho, Liu, Kang, Dee, Edward Christopher, Ng, Kenrick, Liu, Tong, Tse, Gary, Ng, Chi Fai (2023) Long‐term prognostic impact of cardiovascular comorbidities in patients with prostate cancer receiving androgen deprivation therapy: A population‐based competing risk analysis. International Journal of Cancer, 153 (4). pp. 756-764. ISSN 1097-0215. (doi:10.1002/ijc.34557) (KAR id:101282)

Abstract

Our study investigated how adverse cardiovascular outcomes are impacted by cardiovascular comorbidities in patients with prostate cancer treated by androgen deprivation therapy (ADT). Using prospective, population‐based data, all Hong Kong patients with prostate cancer who received ADT during 1 January 1993 to 3 March 2021 were identified and followed up for the endpoint of cardiovascular hospitalization/mortality until 31 September 2021, whichever earlier. Multivariable competing risk regression was used to compare the endpoint's cumulative incidence between different combinations of major cardiovascular comorbidities (heart failure [HF], myocardial infarction [MI], stroke and/or arrhythmia), with noncardiovascular death as competing event. Altogether, 13 537 patients were included (median age 75.9 [interquartile range 70.0‐81.5] years old; median follow‐up 3.3 [1.5‐6.7] years). Compared to those with none of prior HF/MI/stroke/arrhythmia, the incidence of the endpoint was not different in those with only stroke (subhazard ratio [SHR] 1.06 [95% confidence interval (CI): 0.92‐1.23], P = .391), but was higher in those with only HF (SHR 1.67 [1.37‐2.02], P < .001), arrhythmia (SHR 1.63 [1.35‐1.98], P < .001) or MI (SHR 1.43 [1.14‐1.79], P = .002). Those with ≥2 of HF/MI/stroke/arrhythmia had the highest incidence of the endpoint (SHR 1.94 [1.62‐2.33], P < .001), among whom different major cardiovascular comorbidities had similar prognostic impacts, with the number of comorbidities present being significantly prognostic instead. In conclusion, in patients with prostate cancer receiving ADT, the sole presence of HF, MI or arrhythmia, but not stroke, may be associated with elevated cardiovascular risks. In those with ≥2 of HF/MI/stroke/arrhythmia, the number of major cardiovascular comorbidities may be prognostically more important than the type of comorbidities.

Item Type: Article
DOI/Identification number: 10.1002/ijc.34557
Uncontrolled keywords: CANCER EPIDEMIOLOGY, androgen deprivation therapy, cardio‐oncology, comorbidity, hospitalization, mortality, prostate cancer
Subjects: R Medicine
Divisions: Divisions > Division of Natural Sciences > Kent and Medway Medical School
Funders: National Cancer Institute (https://ror.org/04w2jh416)
SWORD Depositor: JISC Publications Router
Depositing User: JISC Publications Router
Date Deposited: 16 May 2023 13:29 UTC
Last Modified: 05 Nov 2024 13:07 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/101282 (The current URI for this page, for reference purposes)

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