Hilton, Kira L.F., Karamalegkos, Antonis A., Allen, Nyasha, Gwynne, Lauren, Streather, Bree, White, Lisa J., Baker, Karen, Henry, Samantha A., Williams, George T., Shepherd, H.J., and others. (2023) Controlling the structure of supramolecular fibre formation for benzothiazole based hydrogels with antimicrobial activity against methicillin resistant Staphylococcus aureus. Journal of Materials Chemistry B, 11 (17). pp. 3958-3968. ISSN 2050-750X. E-ISSN 2050-7518. (doi:10.1039/D3TB00461A) (KAR id:100866)
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Language: English 
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Author's Accepted Manuscript
Language: English DOI for this version: 10.22024/UniKent/01.02.100866.3368523
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| Official URL: https://doi.org/10.1039/D3TB00461A |
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Abstract
Antimicrobial resistance is one of the greatest threats to human health. Gram-positive methicillin resistant Staphylococcus aureus (MRSA), in both its planktonic and biofilm form, is of particular concern. Herein we identify the hydrogelation properties for a series of intrinsically fluorescent, structurally related supramolecular self-associating amphiphiles and determine their efficacy against both planktonic and biofilm forms of MRSA. To further explore the potential translation of this hydrogel technology for real-world applications, the toxicity of the amphiphiles was determined against the eukaryotic multicellular model organism, Caenorhabditis elegans. Due to the intrinsic fluorescent nature of these supramolecular amphiphiles, material characterisation of their molecular self-associating properties included; comparative optical density plate reader assays, rheometry and widefield fluorescence microscopy. This enabled determination of amphiphile structure and hydrogel sol dependence on resultant fibre formation.
| Item Type: | Article |
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| DOI/Identification number: | 10.1039/D3TB00461A |
| Additional information: | For the purpose of open access, the author has applied a CC BY public copyright licence (where permitted by UKRI, an Open Government Licence or CC BY ND public copyright licence may be used instead) to any Author Accepted Manuscript version arising. |
| Uncontrolled keywords: | supramolecular fibre formation; hydrogels; Staphylococcus aureus |
| Subjects: |
Q Science > QD Chemistry Q Science > QR Microbiology |
| Divisions: |
Divisions > Division of Natural Sciences > Biosciences Divisions > Division of Natural Sciences > Chemistry and Forensics |
| Funders: |
University of Kent (https://ror.org/00xkeyj56)
UK Research and Innovation (https://ror.org/001aqnf71) |
| Depositing User: | Jennifer Hiscock |
| Date Deposited: | 12 Apr 2023 14:41 UTC |
| Last Modified: | 04 Mar 2024 17:23 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/100866 (The current URI for this page, for reference purposes) |
University of Kent Author Information
Baker, Karen.
| Creator's ORCID: |
 https://orcid.org/0000-0001-7628-1978
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| CReDIT Contributor Roles: |
Shepherd, H.J..
| Creator's ORCID: |
https://orcid.org/0000-0003-0832-4475
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| CReDIT Contributor Roles: |
Shepherd, Mark.
| Creator's ORCID: |
https://orcid.org/0000-0002-7472-2300
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| CReDIT Contributor Roles: |
Mulvihill, Dan.
| Creator's ORCID: |
https://orcid.org/0000-0003-2502-5274
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| CReDIT Contributor Roles: |
Tullet, Jennifer M.A..
| Creator's ORCID: |
https://orcid.org/0000-0002-2037-526X
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| CReDIT Contributor Roles: |
Ezcurra, Marina.
| Creator's ORCID: |
https://orcid.org/0000-0003-2739-6984
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| CReDIT Contributor Roles: |
Hiscock, Jennifer R..
| Creator's ORCID: |
https://orcid.org/0000-0002-1406-8802
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| CReDIT Contributor Roles: |
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