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Article
| Osborne, James D. and Matthews, Thomas P. and McHardy, Tatiana and Proisy, Nicolas and Cheung, Kwai-Ming J. and Lainchbury, Michael and Brown, Nathan and Walton, Michael I. and Eve, Paul D. and Boxall, Katherine J. and Hayes, Angela and Henley, Alan T. and Valenti, Melanie R. and De Haven Brandon, Alexis K. and Box, Gary and Jamin, Yann and Robinson, Simon P. and Westwood, Isaac M. and van Montfort, Rob L. M. and Leonard, Philip M. and Lamers, Marieke B. A. C. and Reader, John C. and Aherne, G. Wynne and Raynaud, Florence I. and Eccles, Suzanne A. and Garrett, Michelle D. and Collins, Ian (2016) Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737). Journal of Medicinal Chemistry, 59 (11). pp. 5221-5237. ISSN 0022-2623. (doi:https://doi.org/10.1021/acs.jmedchem.5b01938) (Full text available) |
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| Walton, Mike I. and Eve, Paul D. and Hayes, Angela and Henley, Alan T. and Valenti, Melanie R. and De Haven Brandon, Alexis K. and Boxall, Kathy J. and Box, Gary and Tall, Matthew and Swales, Karen and Matthews, Thomas P. and McHardy, Tatiana and Lainchbury, Michael and Osborne, James and Hunter, Jill E. and Perkins, Neil D. and Aherne, G. Wynne and Reader, John C. and Raynaud, Florence I. and Eccles, Suzanne A. and Collins, Ian and Garrett, Michelle D. (2015) The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eµ-MYC driven B-cell lymphoma. Oncotarget, 7 (3). pp. 2329-2342. E-ISSN 1949-2553. (doi:https://doi.org/10.18632/oncotarget.4919) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Sadok, Amine and McCarthy, Afshan and Caldwell, John and Collins, Ian and Garrett, Michelle D. and Yeo, Maggie and Hooper, Steven and Sahai, Erik and Kuemper, Sandra and Mardakheh, Faraz K. and Marshall, Christopher J. (2015) Rho Kinase Inhibitors Block Melanoma Cell Migration and Inhibit Metastasis. Cancer Research, 75 (11). pp. 2272-2284. ISSN 0008-5472. (doi:https://doi.org/10.1158/0008-5472.CAN-14-2156) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Touchefeu, Yann and Khan, Aadil A. and Borst, Gerben and Zaidi, Shane H. and McLaughlin, Martin and Roulstone, Victoria and Mansfield, David and Kyula, Joan and Pencavel, Tim and Karapanagiotou, Eleni M. and Clayton, Jamie and Federspiel, Mark J. and Russell, Steve J. and Garrett, Michelle D. and Collins, Ian and Harrington, Kevin J. (2013) Optimising measles virus-guided radiovirotherapy with external beam radiotherapy and specific checkpoint kinase 1 inhibition. Radiotherapy and Oncology, 108 (1). pp. 24-31. ISSN 0167-8140. (doi:https://doi.org/10.1016/j.radonc.2013.05.036) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Wang, Qiming Jane and Silva-Santisteban, M. Cris and Westwood, Isaac M. and Boxall, Kathy and Brown, Nathan and Peacock, Sam and McAndrew, Craig and Barrie, Elaine and Richards, Meirion and Mirza, Amin and Oliver, Antony W. and Burke, Rosemary and Hoelder, Swen and Jones, Keith and Aherne, G. Wynne and Blagg, Julian and Collins, Ian and Garrett, Michelle D. and van Montfort, Rob L. M. (2013) Fragment-Based Screening Maps Inhibitor Interactions in the ATP-Binding Site of Checkpoint Kinase 2. PLoS ONE, 8 (6). e65689. ISSN 1932-6203. (doi:https://doi.org/10.1371/journal.pone.0065689) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Lainchbury, Michael and Matthews, Thomas P. and McHardy, Tatiana and Boxall, Kathy J. and Walton, Michael I. and Eve, Paul D. and Hayes, Angela and Valenti, Melanie R. and de Haven Brandon, Alexis K. and Box, Gary and Aherne, G. Wynne and Reader, John C. and Raynaud, Florence I. and Eccles, Suzanne A. and Garrett, Michelle D. and Collins, Ian (2012) Discovery of 3-Alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as Selective, Orally Bioavailable CHK1 Inhibitors. Journal of Medicinal Chemistry, 55 (22). pp. 10229-10240. ISSN 0022-2623. (doi:https://doi.org/10.1021/jm3012933) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Borst, Gerben R. and McLaughlin, Martin and Kyula, Joan N. and Neijenhuis, Sari and Khan, Aadil and Good, James and Zaidi, Shane and Powell, Ned G. and Meier, Pascal and Collins, Ian and Garrett, Michelle D. and Verheij, Marcel and Harrington, Kevin J. (2012) Targeted Radiosensitization by the Chk1 Inhibitor SAR-020106. International Journal of Radiation Oncology Biology Physics, 85 (4). pp. 1110-1118. ISSN 0360-3016. (doi:https://doi.org/10.1016/j.ijrobp.2012.08.006) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Reader, John C. and Matthews, Thomas P. and Klair, Suki and Cheung, Kwai-Ming J. and Scanlon, Jane and Proisy, Nicolas and Addison, Glynn and Ellard, John and Piton, Nelly and Taylor, Suzanne and Cherry, Michael and Fisher, Martin and Boxall, Kathy and Burns, Samantha and Walton, Michael I. and Westwood, Isaac M. and Hayes, Angela and Eve, Paul and Valenti, Melanie and de Haven Brandon, Alexis and Box, Gary and van Montfort, Rob L. M. and Williams, David H. and Aherne, G. Wynne and Raynaud, Florence I. and Eccles, Suzanne A. and Garrett, Michelle D. and Collins, Ian (2011) Structure-Guided Evolution of Potent and Selective CHK1 Inhibitors through Scaffold Morphing. Journal of Medicinal Chemistry, 54 (24). pp. 8328-8342. ISSN 0022-2623. (doi:https://doi.org/10.1021/jm2007326) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Caldwell, John J. and Welsh, Emma J. and Matijssen, Cornelis and Anderson, Victoria E. and Antoni, Laurent and Boxall, Kathy and Urban, Frederique and Hayes, Angela and Raynaud, Florence I. and Rigoreau, Laurent J. M. and Raynham, Tony and Aherne, G. Wynne and Pearl, Laurence H. and Oliver, Antony W. and Garrett, Michelle D. and Collins, Ian (2010) Structure-Based Design of Potent and Selective 2-(Quinazolin-2-yl)phenol Inhibitors of Checkpoint Kinase 2. Journal of Medicinal Chemistry, 54 (2). pp. 580-590. ISSN 0022-2623. (doi:https://doi.org/10.1021/jm101150b) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Matthews, Thomas P. and McHardy, Tatiana and Klair, Suki and Boxall, Kathy and Fisher, Martin and Cherry, Michael and Allen, Charlotte E. and Addison, Glynn J. and Ellard, John and Aherne, G. Wynne and Westwood, Isaac M. and Montfort, Rob van and Garrett, Michelle D. and Reader, John C. and Collins, Ian (2010) Design and evaluation of 3,6-di(hetero)aryl imidazo[1,2-a]pyrazines as inhibitors of checkpoint and other kinases. Bioorganic & Medicinal Chemistry Letters, 20 (14). pp. 4045-4049. ISSN 0960-894X. (doi:https://doi.org/10.1016/j.bmcl.2010.05.096) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| McHardy, Tatiana and Caldwell, John J. and Cheung, Kwai-Ming and Hunter, Lisa J. and Taylor, Kevin and Rowlands, Martin and Ruddle, Ruth and Henley, Alan and de Haven Brandon, Alexis and Valenti, Melanie and Davies, Thomas G. and Fazal, Lynsey and Seavers, Lisa and Raynaud, Florence I. and Eccles, Suzanne A. and Aherne, G. Wynne and Garrett, Michelle D. and Collins, Ian (2010) Discovery of 4-Amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides As Selective, Orally Active Inhibitors of Protein Kinase B (Akt). Journal of Medicinal Chemistry, 53 (5). pp. 2239-2249. ISSN 0022-2623. (doi:https://doi.org/10.1021/jm901788j) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
| Hilton, Stephen and Naud, Sebastien and Caldwell, John J. and Boxall, Kathy and Burns, Samantha and Anderson, Victoria E. and Antoni, Laurent and Allen, Charlotte E. and Pearl, Laurence H. and Oliver, Antony W. and Wynne Aherne, G. and Garrett, Michelle D. and Collins, Ian (2009) Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2. Bioorganic & Medicinal Chemistry, 18 (2). pp. 707-718. ISSN 0968-0896. (doi:https://doi.org/10.1016/j.bmc.2009.11.058) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) |
