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Association Between Atherosclerosis-Related Cardiovascular Disease and Uveitis: A Systematic Review and Meta-Analysis

Gao, Xinyi, Lv, Tonglian, Li, Guangping, Tse, Gary, Liu, Tong (2022) Association Between Atherosclerosis-Related Cardiovascular Disease and Uveitis: A Systematic Review and Meta-Analysis. Diagnostics, 12 (12). Article Number 3178. ISSN 2075-4418. (doi:10.3390/diagnostics12123178) (KAR id:99697)


Background: Uveitis is not only an intraocular inflammatory disease, but also an indicator of systemic inflammation. It is unclear whether uveitis can increase the risk of cardiovascular disease (CVD) through the atherosclerotic pathway.

Methods: PubMed and Embase databases were searched until 5 September, 2022. Original studies investigating uveitis and cardiovascular events were selected. The random-effects model was used to calculate the difference of groups in pooled estimates.

Results: A total of six observational studies that included mainly ankylosing spondylitis (AS) patients were included. Of these, three studies reported data on carotid plaques and carotid intima-media thickness (cIMT) and the other three studies provided data on atherosclerosis-related CVD. No significant difference was found in cIMT between uveitis and controls (MD = 0.01, 95% CI = -0.03-0.04, <i>p</i> = 0.66), consistent with the findings of carotid plaque incidence (OR = 1.30, 95% CI = 0.71-2.41, <i>p</i> = 0.39). However, uveitis was associated with a 1.49-fold increase in atherosclerosis-related CVD (HR = 1.49, 95% CI = 1.20-1.84, <i>p</i> = 0.0002).

Conclusions: Uveitis is a predictor of atherosclerosis-related CVD in AS patients. For autoimmune disease patients with uveitis, earlier screening of cardiovascular risk factors and the implementation of corresponding prevention strategies may be associated with a better prognosis.

Item Type: Article
DOI/Identification number: 10.3390/diagnostics12123178
Uncontrolled keywords: Atherosclerosis, Ankylosing spondylitis, Intima-media thickness, Uveitis, Cardiovascular Risk, Carotid Plaques
Subjects: Q Science
R Medicine
Divisions: Divisions > Division of Natural Sciences > Kent and Medway Medical School
Funders: University of Kent (
SWORD Depositor: JISC Publications Router
Depositing User: JISC Publications Router
Date Deposited: 27 Jan 2023 11:12 UTC
Last Modified: 10 May 2024 13:06 UTC
Resource URI: (The current URI for this page, for reference purposes)

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