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A delicate balance between antibody evasion and ACE2 affinity for Omicron BA.2.75

Huo, Jiandong, Dijokaite-Guraliuc, Aiste, Liu, Chang, Das, Raksha, Supasa, Piyada, Selvaraj, Muneeswaran, Nutalai, Rungtiwa, Zhou, Daming, Mentzer, Alexander J., Skelly, Donal, and others. (2023) A delicate balance between antibody evasion and ACE2 affinity for Omicron BA.2.75. Cell Reports, 42 (1). Article Number 111903. ISSN 2211-1247. (doi:10.1016/j.celrep.2022.111903) (KAR id:99225)

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Variants of SARS CoV-2 have caused successive global waves of infection. These variants, with multiple mutations in the spike protein are thought to facilitate escape from natural and vaccine-induced immunity and often increase in the affinity for ACE2. The latest variant to cause concern is BA.2.75, identified in India where it is now the dominant strain, with evidence of wider dissemination. BA.2.75 is derived from BA.2 and contains four additional mutations in the receptor binding domain (RBD). Here we perform an antigenic and biophysical characterization of BA.2.75, revealing an interesting balance between humoral evasion and ACE2 receptor affinity. ACE2 affinity for BA.2.75 is increased 9-fold compared to BA.2; there is also evidence of escape of BA.2.75 from immune serum, particularly that induced by Delta infection which may explain the rapid spread in India, where BA.2.75 is now the dominant variant. ACE2 affinity appears to be prioritised over greater escape.

Item Type: Article
DOI/Identification number: 10.1016/j.celrep.2022.111903
Additional information: For the purpose of open access, the author has applied a CC BY public copyright licence (where permitted by UKRI, an Open Government Licence or CC BY ND public copyright licence may be used instead) to any Author Accepted Manuscript version arising.
Uncontrolled keywords: SARS-CoV-2, spike, RBD, immune escape, COVID-19, ACE2 receptor, variant, variant of concern, antigenic variation, BA.2.75
Subjects: Q Science > QR Microbiology > QR355 Virology
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Funders: Wellcome Trust (
Depositing User: Nigel Temperton
Date Deposited: 17 Dec 2022 14:12 UTC
Last Modified: 11 Apr 2023 14:56 UTC
Resource URI: (The current URI for this page, for reference purposes)

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