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The role of multimorbidity in short-term mortality of lung cancer patients in Spain: a population-based cohort study

Niksic, Maja, Redondo-Sanchez, Daniel, Chang, Yoe-Ling, Rodriguez-Barranco, Miguel, Exposito-Hernandez, Jose, Marcos-Gragera, Rafael, Oliva-Poch, Ester, Bosch-Barrera, Joaquim, Sanchez, Maria-Jose, Luque-Fernandez, Miguel Angel and others. (2021) The role of multimorbidity in short-term mortality of lung cancer patients in Spain: a population-based cohort study. BMC Cancer, 21 . Article Number 1048. ISSN 1471-2407. (doi:10.1186/s12885-021-08801-9) (KAR id:98807)


Aim: Chronic diseases often occur simultaneously and tend to be associated with adverse health outcomes, but limited research has been undertaken to understand their role in lung cancer mortality. Therefore, this study aims to describe the prevalence and patterns of having one (comorbidity) or ≥ 2 chronic diseases (multimorbidity) among lung cancer patients in Spain, and to examine the association between comorbidity or multimorbidity and short-term mortality risk at six months after cancer diagnosis. Methods: In this population-based cohort study, data were drawn from two Spanish population-based cancer registries, Girona and Granada, and electronic health records. We identified 1259 adult lung cancer patients, diagnosed from 1st January 2011 to 31st December 2012. We identified the most common patterns of individual comorbidities and their pairwise correlations. We used a flexible parametric modelling approach to assess the overall short-term mortality risk 6 months after cancer diagnosis by levels of comorbidity after adjusting for age, sex, smoking status, province of residence, surgery, cancer stage, histology, and body mass index. Results: We found high prevalence of comorbidity in lung cancer patients, especially among the elderly, men, those diagnosed with advanced-stage tumours, smokers, and obese patients. The most frequent comorbidities were chronic obstructive pulmonary disease (36.6%), diabetes (20.7%) and heart failure (16.8%). The strongest pairwise correlation was the combination of heart failure with renal disease (r = 0.20, p < 0.01), and heart failure with diabetes (r = 0.16, p < 0.01). Patients with either one or two or more comorbidities had 40% higher overall mortality risk than those without comorbidities (aHR for comorbidity: 1.4, 95%CI: 1.1–1.7; aHR for multimorbidity: 1.4, 95%CI: 1.1–1.8), when relevant confounding factors were considered.

Item Type: Article
DOI/Identification number: 10.1186/s12885-021-08801-9
Subjects: R Medicine
Divisions: Divisions > Division for the Study of Law, Society and Social Justice > School of Social Policy, Sociology and Social Research > Centre for Health Services Studies
Funders: Instituto de Salud Carlos III (
Depositing User: George Austin-Coskry
Date Deposited: 06 Dec 2022 14:32 UTC
Last Modified: 04 Mar 2024 16:00 UTC
Resource URI: (The current URI for this page, for reference purposes)

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