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Association between visit-to-visit Lipid variability and incident cancer: A population-based cohort study

Chan, Jeffrey Shi Kai, Satti, Danish Iltaf, Lee, Yan Hiu Athena, Bin Waleed, Khalid, Tang, Pias, Mahalwar, Gauranga, Minhas, Abdul Mannan Khan, Roever, Leonardo, Biondi-Zoccai, Giuseppe, Leung, Fung Ping, and others. (2023) Association between visit-to-visit Lipid variability and incident cancer: A population-based cohort study. Current Problems in Cardiology, 48 (1). Article Number 101421. ISSN 0146-2806. (doi:10.1016/j.cpcardiol.2022.101421) (KAR id:98705)


Dyslipidemia is associated with increased cancer risk. However, the prognostic value of visit-to-visit lipid variability (VVLV) is unexplored in this regard. To investigate the associations between the VVLV and the risk of incident cancer, we conducted a retrospective cohort study on adult patients attending a family medicine clinic in Hong Kong during 2000-2003, excluding those with <3 tests for low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, and total cholesterol (TC) each, those with prior cancer diagnosis, and those with <1 year of follow-up. Visit-to-visit LDL-C, HDL-C, TC, and triglycerides variabilities were measured by the coefficient of variation (CV). Patients were followed up until 31st December 2019 for the primary outcome of incident cancer. Altogether, 69,186 patients were included (26,679 males (38.6%); mean age 60 ± 13 years; mean follow-up 16 ± 3 years); 7958 patients (11.5%) had incident cancer. Higher variability of LDL-C, HDL-C, TC, and TG was associated with higher risk of incident cancer. Patients in the third tercile of the CV of LDL-C (adjusted hazard ratio (aHR) against first tercile 1.06 [1.00, 1.12], P = 0.049), HDL-C (aHR 1.37 [1.29, 1.44], P< 0.001), TC (aHR 1.10 [1.04, 1.17], P = 0.001), and TG (aHR 1.11 [1.06, 1.18], P < 0.001) had the highest risks of incident cancer. Among these, only HDL-C variability remained associated with the risk of incident cancer in users of statins/fibrates. To conclude, higher VVLV was associated with significantly higher long-term risks of incident cancer. VVLV may be a clinically useful tool for cancer risk stratification.

Item Type: Article
DOI/Identification number: 10.1016/j.cpcardiol.2022.101421
Uncontrolled keywords: Dyslipidemia, VVLV
Subjects: R Medicine > R Medicine (General)
Divisions: Divisions > Division of Natural Sciences > Kent and Medway Medical School
Depositing User: Manfred Gschwandtner
Date Deposited: 05 Dec 2022 18:27 UTC
Last Modified: 13 Dec 2022 11:16 UTC
Resource URI: (The current URI for this page, for reference purposes)
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