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Atrial cardiomyopathy: an emerging cause of the embolic stroke of undetermined source

Ning, Yuye, Tse, Gary, Luo, Guogang, Li, Guoliang (2021) Atrial cardiomyopathy: an emerging cause of the embolic stroke of undetermined source. Frontiers in Cardiovascular Medicine, 8 . Article Number 674612. ISSN 2297-055X. (doi:10.3389/fcvm.2021.674612) (KAR id:98432)


Nearly 30% of ischemic strokes have an unknown cause, which are referred to as cryptogenic strokes (CS). Imaging studies suggest that a large proportion of these patients show features that are consistent with embolism, and thus the term embolic stroke of undetermined source (ESUS) was proposed to describe these CS patients. Atrial cardiomyopathy predisposes to thrombus formation and thus embolic stroke even in the absence of atrial fibrillation (AF). This may provide a mechanistic link with ESUS, suggesting that anticoagulant therapy may be more beneficial than antiplatelet therapy in ESUS patients with atrial cardiomyopathy. The present review discusses the concept of atrial cardiomyopathy and ESUS and the relationship between them based on the mechanisms and clinical evidence, suggests that atrial cardiomyopathy may be a potential mechanism of ESUS, and highlights a theoretical basis that supports that anticoagulant therapy may be more applicable to ESUS patients with atrial cardiomyopathy and aims to help us better understand and identify the risk of ESUS, thereby improving the management of these patients in clinical practice.

Item Type: Article
DOI/Identification number: 10.3389/fcvm.2021.674612
Uncontrolled keywords: cardiac rhythm abnormalities, risk stratification, atrial cardiomyopathy, structural heart disease, embolic stroke of undetermined source
Subjects: R Medicine
Divisions: Divisions > Division of Natural Sciences > Kent and Medway Medical School
Depositing User: Gary Tse
Date Deposited: 28 Nov 2022 09:27 UTC
Last Modified: 30 Nov 2022 14:26 UTC
Resource URI: (The current URI for this page, for reference purposes)

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