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Substituted Pyrazolo[3,4-d]pyrimidines: Microwave-Assisted, Solvent-Free Synthesis and Biological Evaluation

Oliveira-Campos, Ana M. F., Sivasubramanian, Aravind, Rodrigues, Lígia M., Seijas, Julio A., Pilar Vázquez-Tato, M., Peixoto, Francisco, Abreu, Carlos G., Cidade, Honorina, Oliveira, Ana, Pinto, Madalena and others. (2008) Substituted Pyrazolo[3,4-d]pyrimidines: Microwave-Assisted, Solvent-Free Synthesis and Biological Evaluation. Helvetica Chimica Acta, 91 (7). pp. 1336-1345. ISSN 0018-019X. (doi:10.1002/hlca.200890145) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:98389)

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A simple and efficient method has been developed for the synthesis of various pyrazolo[3,4-d]pyrimidines by using microwave irradiation under solvent-free conditions. The advantages of applying microwave irradiation compared with the classical method were demonstrated. The structures of all the compounds were confirmed by the usual techniques and, in two cases, by X-ray analysis. The compounds did not display appreciable ability to inhibit xanthine oxidase activity. Screening for antifungal activity showed that some derivatives were active against four fungi, with more significant results for Botrytis.

Item Type: Article
DOI/Identification number: 10.1002/hlca.200890145
Subjects: R Medicine
Divisions: Divisions > Division of Natural Sciences > Kent and Medway Medical School
Depositing User: Ana Oliveira
Date Deposited: 27 Nov 2022 16:18 UTC
Last Modified: 02 Dec 2022 09:46 UTC
Resource URI: (The current URI for this page, for reference purposes)
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