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Postmortem Redistribution of Tramadol and O-Desmethyltramadol

Costa, I., Oliveira, Ana, Guedes de Pinho, P., Teixeira, H. M., Moreira, R., Carvalho, F., Jorge Dinis-Oliveira, R. (2013) Postmortem Redistribution of Tramadol and O-Desmethyltramadol. Journal of Analytical Toxicology, 37 (9). pp. 670-675. ISSN 0146-4760. (doi:10.1093/jat/bkt084) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:98386)

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Tramadol is a widely used analgesic opioid for moderate-to-severe pain due to its efficacy and safety. Although tramadol induces less adverse effects compared with other opioids, an increased number of documented cases of dependence, abuse, intentional overdose or intoxication have been described. In fatal intoxication, the interpretation of the probable cause of death often relies on the measurement of the tramadol concentration in blood. However, postmortem redistribution (PMR) may affect the results and therefore bias the autopsy report. In the present study, the postmortem cardiac and femoral blood samples from 15 cases of fatal tramadol intoxication were obtained to assess the PMR of tramadol and its main active metabolite, O-desmethyltramadol (M1). Toxicological analysis was performed by the gas chromatography–electron impact-mass spectrometry (GC–EI-MS) method, previously developed and validated for the quantification of both analytes. The cardiac-to-femoral blood ratios of 1.40 and 1.28 were obtained for tramadol and M1, respectively. Results were compared with those in the literature and it was possible to conclude that femoral blood should be considered for quantitative interpretations in fatal cases of tramadol intoxication.

Item Type: Article
DOI/Identification number: 10.1093/jat/bkt084
Subjects: R Medicine
Divisions: Divisions > Division of Natural Sciences > Kent and Medway Medical School
Depositing User: Ana Oliveira
Date Deposited: 27 Nov 2022 16:30 UTC
Last Modified: 02 Dec 2022 09:53 UTC
Resource URI: (The current URI for this page, for reference purposes)

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Oliveira, Ana.

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