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Right ventricular outflow tract endocardial unipolar substrate mapping: implications in risk stratification of Brugada syndrome

Baranchuk, Adrian, Hocini, Meleze, Sacher, Frederic, Prappa, Efstathia, Niarchou, Panagioula, Bazoukis, George, Liu, Tong, Tse, Gary, Korantzopoulos, Panagiotis, Dragasis, Stylianos, and others. (2022) Right ventricular outflow tract endocardial unipolar substrate mapping: implications in risk stratification of Brugada syndrome. Reviews in Cardiovascular Medicine, 23 (2). Article Number 044. ISSN 1530-6550. (doi:10.31083/j.rcm2302044) (KAR id:98273)

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Brugada syndrome (BrS) is a complex arrhythmogenic disease displaying electrical and micro-structural abnormalities mainly located at the epicardium of the right ventricular outflow tract (RVOT). It is well-known that fibrosis, fatty infiltration, inflammation and reduced gap junction expression have been demonstrated at the epicardial anterior aspect of the RVOT providing the arrhythmogenic substrate for ventricular arrhythmic events in BrS. A number of models have been proposed for the risk stratification of patients with BrS. Endocardial unipolar electroanatomical mapping is an emerging tool that has been reintroduced to identify and quantify epicardial electrical abnormalities. Interestingly, current findings correlate the presence of large-sized endocardial unipolar electroanatomical abnormalities with either ventricular fibrillation inducibility during programmed ventricular stimulation or symptom status. This review aims to present existing data about the role of endocardial unipolar electroanatomical mapping for the identification of RVOT epicardial abnormalities as well as its potential clinical implications in risk stratification of BrS.

Item Type: Article
DOI/Identification number: 10.31083/j.rcm2302044
Uncontrolled keywords: Brugada syndrome, electroanatomical mapping, risk stratification
Subjects: R Medicine
Divisions: Divisions > Division of Natural Sciences > Kent and Medway Medical School
Funders: University of Kent (
Depositing User: Gary Tse
Date Deposited: 23 Nov 2022 12:16 UTC
Last Modified: 23 Nov 2022 12:16 UTC
Resource URI: (The current URI for this page, for reference purposes)
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