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Electrocardiographic features of immune checkpoint inhibitor-associated myocarditis

Song, Wenhua, Zheng, Yi, Dong, Mei, Zhong, Lin, Bazoukis, George, Perone, Francesco, Li, Guangping, Ng, Chi Fai, Baranchuk, Adrian, Tse, Gary, and others. (2023) Electrocardiographic features of immune checkpoint inhibitor-associated myocarditis. Current Problems in Cardiology, 48 (2). Article Number 101478. ISSN 0146-2806. (doi:10.1016/j.cpcardiol.2022.101478) (KAR id:98195)

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Immune checkpoint inhibitors (ICIs) are associated with immune-related adverse events including myocarditis, whilst improving cancer-related outcomes. There is thus a clinical need to identify electrocardiographic manifestations of ICI-related myocarditis to guide clinical management. PubMed was searched for clinical studies and case reports describing electrocardiographic changes in patients with ICI-related myocarditis. A total of six clinical studies and 79 case reports were included. This revealed a range of presentations for patients on ICIs, including supraventricular arrhythmias, ventricular arrhythmias and heart block, and new changes of ST-T segment unrelated to coronary artery disease, ST-segment elevation or depression and T-wave abnormalities. Several patients showed low voltages in multiple leads and new onset Q-wave development. Patients with ICI-related myocarditis may develop new arrhythmia and ST-T changes, and infrequently low voltages in multiple leads.

Item Type: Article
DOI/Identification number: 10.1016/j.cpcardiol.2022.101478
Additional information: ** From PubMed via Jisc Publications Router ** History: received 18-10-2022; accepted 26-10-2022.
Uncontrolled keywords: myocarditis, electrocardiogram, immune checkpoint inhibitors
Subjects: R Medicine
Divisions: Divisions > Division of Natural Sciences > Kent and Medway Medical School
SWORD Depositor: JISC Publications Router
Depositing User: JISC Publications Router
Date Deposited: 24 Nov 2022 11:56 UTC
Last Modified: 25 Nov 2022 09:49 UTC
Resource URI: (The current URI for this page, for reference purposes)
Tse, Gary:
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