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Exploring electrophysiological markers of auditory predictive processes and pathological ageing in adults with Down's syndrome

Avancini, Chiara, Jennings, Sally, Chennu, Srivas, Noreika, Valdas, Le, April, Bekinschtein, Tristan A., Walpert, Madeleine J., Clare, Isabel C. H., Holland, Anthony J., Zaman, Shahid H., and others. (2022) Exploring electrophysiological markers of auditory predictive processes and pathological ageing in adults with Down's syndrome. European Journal of Neuroscience, 56 (9). pp. 5615-5636. ISSN 1460-9568. (doi:10.1111/ejn.15762) (KAR id:98189)

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Down’s syndrome is associated with pathological ageing and a propensity for early-onset Alzheimer’s disease. The early symptoms of dementia in people with Down’s syndrome may reflect frontal lobe vulnerability to amyloid depo-sition. Auditory predictive processes rely on the bilateral auditory cortices with the recruitment of frontal cortices and appear to be impaired in pathologies characterized by compromised frontal lobe. Hence, auditory predictive pro-cesses were investigated to assess Down’s syndrome pathology and its relation-ship with pathological ageing. An auditory electroencephalography (EEG)global–local paradigm was presented to the participants, in which oddball stimuli could either violate local or higher level global rules. We characterised predictive processes in individuals with Down’s syndrome and their relation-ship with pathological ageing, with a focus on the EEG event-related potential called Mismatch Negativity (MMN) and the P300. In Down’s syndrome, we also evaluated the EEG components as predictor of cognitive decline 1 year later. We found that predictive processes of detection of auditory violations are overall preserved in Down’s syndrome but also that the amplitude of the MMN to local deviancies decreases with age. However, the 1-year follow-up of Down’s syndrome found that none of the ERPs measures predicted subsequent cognitive decline. The present study provides a novel characterization of elec-trophysiological markers of local and global predictive processes in Down’s syndrome.

Item Type: Article
DOI/Identification number: 10.1111/ejn.15762
Additional information: ** Article version: VoR ** From Crossref journal articles via Jisc Publications Router ** History: epub 24-07-2022; issued 24-07-2022. ** Licence for VoR version of this article starting on 24-07-2022: For the purpose of open access, the author has applied a CC BY public copyright licence (where permitted by UKRI, an Open Government Licence or CC BY ND public copyright licence may be used instead) to any Author Accepted Manuscript version arising
Uncontrolled keywords: Ageing, auditory violation, dementia, MMN, P300, prediction error
Subjects: Q Science
Divisions: Divisions > Division of Computing, Engineering and Mathematical Sciences > School of Computing
Funders: Medical Research Council (
SWORD Depositor: JISC Publications Router
Depositing User: JISC Publications Router
Date Deposited: 25 Nov 2022 12:51 UTC
Last Modified: 28 Nov 2022 11:50 UTC
Resource URI: (The current URI for this page, for reference purposes)
Avancini, Chiara:
Jennings, Sally:
Chennu, Srivas:
Noreika, Valdas:
Bekinschtein, Tristan A.:
Walpert, Madeleine J.:
Clare, Isabel C. H.:
Holland, Anthony J.:
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