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Dissolution Improvement of Progesterone and Testosterone via Impregnation on Mesoporous Silica Using Supercritical Carbon Dioxide

Ajiboye, Adejumoke Lara, Jacopin, Amélie, Mattern, Claudia, Nandi, Uttom, Hurt, Andrew, Trivedi, Vivek (2022) Dissolution Improvement of Progesterone and Testosterone via Impregnation on Mesoporous Silica Using Supercritical Carbon Dioxide. AAPS PharmSciTech, 23 (8). Article Number 302. ISSN 1530-9932. (doi:10.1208/s12249-022-02453-z) (KAR id:98122)


Progesterone (PRG) and testosterone (TST) were impregnated on mesoporous silica (ExP) particles via supercritical carbon dioxide (scCO2) processing at various pressures (10–18 MPa), temperatures (308.2–328.2 K), and time (30–360 min). The impact of a co-solvent on the impregnation was also studied at the best determined pressure and temperature. The properties of the drug embedded in silica particles were analysed via gas chromatography (GC), attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy, X-ray diffraction (XRD), differential scanning calorimetry (DSC), and nitrogen adsorption. An impregnation of 1 to 82 mg/g for PRG and 0.1 to 16 mg/g for TST was obtained depending on the processing parameters. There was a significant effect of pressure, time, and co-solvent on the impregnation efficiency. Generally, an increase in time and pressure plus the use of co-solvent led to an improvement in drug adsorption. Conversely, a rise in temperature resulted in lower impregnation of both TST and PRG on ExP. There was a substantial increase in the dissolution rate (> 90% drug release within the first 2 min) of both TST and PRG impregnated in silica particles when compared to the unprocessed drugs. This dissolution enhancement was attributed to the amorphisation of both drugs due to their adsorption on mesoporous silica.

Item Type: Article
DOI/Identification number: 10.1208/s12249-022-02453-z
Additional information: ** From Springer Nature via Jisc Publications Router ** History: received 11-08-2022; accepted 31-10-2022; registration 02-11-2022; pub-electronic 16-11-2022; online 16-11-2022; collection 12-2022. ** Licence for this article:
Uncontrolled keywords: Dissolution improvement, drug impregnation, green processing, mesoporous silica, progesterone, supercritical carbon dioxide, supercritical fuid, testosterone
Subjects: R Medicine
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Funders: University of Kent (
SWORD Depositor: JISC Publications Router
Depositing User: Vivek Trivedi
Date Deposited: 18 Nov 2022 11:58 UTC
Last Modified: 08 Dec 2022 11:21 UTC
Resource URI: (The current URI for this page, for reference purposes)

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