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Elevated Expression of LGR5 and WNT Signaling Factors in Neuroblastoma Cells With Acquired Drug Resistance

Clark-Corrigall, John, Myssina, Svetlana, Michaelis, Martin, Cinatl, Jindrich, Ahmed, Shafiq, Carr-Wilkinson, Jane (2022) Elevated Expression of LGR5 and WNT Signaling Factors in Neuroblastoma Cells With Acquired Drug Resistance. Cancer Investigation, 41 (2). pp. 173-182. ISSN 1532-4192. (doi:10.1080/07357907.2022.2136682) (KAR id:98091)


Neuroblastoma (NB) is a pediatric solid cancer with high fatality, relapses, and acquired resistance to chemotherapy, that requires new therapeutic approaches to improve survival. LGR5 is a receptor that potentiates WNT/signaling pathway and has been reported to promote development and survival in several adult cancers. In this study we investigated LGR5 expression in a panel of NB cell lines with acquired resistance to vincristine or doxorubicin. We show LGR5-LRP6 cooperation with enhanced expression in drug resistant NB cell lines compared to parental cells, suggesting a role for LGR5 in the emergence of drug resistance, warranting further investigation.

Item Type: Article
DOI/Identification number: 10.1080/07357907.2022.2136682
Additional information: ** From Crossref journal articles via Jisc Publications Router ** History: epub 07-11-2022; issued 07-11-2022.
Uncontrolled keywords: LGR5, LRP6 WNT pathway, neuroblastoma, acquired drug resistance
Subjects: Q Science
R Medicine
Divisions: Divisions > Division of Natural Sciences > Biosciences
Funders: University of Sunderland (
SWORD Depositor: JISC Publications Router
Depositing User: JISC Publications Router
Date Deposited: 18 Nov 2022 13:07 UTC
Last Modified: 07 Nov 2023 00:00 UTC
Resource URI: (The current URI for this page, for reference purposes)

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