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Pancreatic cancer survival trends in the US from 2001 to 2014: a CONCORD-3 study

Niksic, Maja, Minicozzi, Pamela, Weir, Hannah K, Zimmerman, Heather, Maria J, Schymura, Rees, Judith R, Coleman, Michel P, Allemani, Claudia (2022) Pancreatic cancer survival trends in the US from 2001 to 2014: a CONCORD-3 study. Cancer Communications, 43 (1). pp. 87-99. ISSN 2523-3548. (doi:10.1002/cac2.12375) (KAR id:97956)



Survival from pancreatic cancer is low worldwide. In the US, the 5-year relative survival has been slightly higher for women, whites and younger patients than for their counterparts, and differences in age and stage at diagnosis may contribute to this pattern. We aimed to examine trends in survival by race, stage, age and sex for adults (15-99 years) diagnosed with pancreatic cancer in the US.


This population-based study included 399,427 adults registered with pancreatic cancer in 41 US state cancer registries during 2001-2014, with follow-up to December 31, 2014. We estimated age-specific and age-standardized net survival at 1 and 5 years.


Overall, 12.3% of patients were blacks, and 84.2% were whites. About 9.5% of patients were diagnosed with localized disease, but 50.5% were diagnosed at an advanced stage; slightly more among blacks, mainly among men. No substantial changes were seen over time (2001-2003, 2004-2008, 2009-2014). In general, 1-year net survival was higher in whites than in blacks (26.1% vs. 22.1% during 2001-2003, 35.1% vs. 31.4% during 2009-2014). This difference was particularly evident among patients with localized disease (49.6% in whites vs. 44.6% in blacks during 2001-2003, 60.1% vs. 55.3% during 2009-2014). The survival gap between blacks and whites with localized disease was persistent at 5 years after diagnosis, and it widened over time (from 24.0% vs. 21.3% during 2001-2003 to 39.7% vs. 31.0% during 2009-2014). The survival gap was wider among men than among women.


gaps in 1-and 5-year survival between blacks and whites were persistent throughout 2001-2014, especially for patients diagnosed with a localized tumor, for which surgery is currently the only treatment modality with the potential for cure.

Item Type: Article
DOI/Identification number: 10.1002/cac2.12375
Uncontrolled keywords: Population-based cancer registries, net survival, stage, pancreatic cancer, race/ethnicity
Subjects: R Medicine
Divisions: Divisions > Division for the Study of Law, Society and Social Justice > School of Social Policy, Sociology and Social Research > Centre for Health Services Studies
Depositing User: George Austin-Coskry
Date Deposited: 14 Nov 2022 10:11 UTC
Last Modified: 03 Feb 2023 12:25 UTC
Resource URI: (The current URI for this page, for reference purposes)

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