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Biological characteristics of the Trypanosoma cruzi Arequipa strain make it a good model for Chagas disease drug discovery

Martín-Escolano, Rubén, Rosales, María José, Marín, Clotilde (2022) Biological characteristics of the Trypanosoma cruzi Arequipa strain make it a good model for Chagas disease drug discovery. Acta Tropica, 236 . Article Number 106679. ISSN 1873-6254. (doi:10.1016/j.actatropica.2022.106679) (KAR id:97108)

Abstract

Trypanosoma cruzi, the causative agent of Chagas disease (CD), is a genuine parasite with tremendous genetic diversity and a complex life cycle. Scientists have studied this disease for more than 100 years, and CD drug discovery has been a mainstay due to the absence of an effective treatment. Technical advances in several areas have contributed to a better understanding of the complex biology and life cycle of this parasite, with the aim of designing the ideal profile of both drug and therapeutic options to treat CD. Here, we present the T. cruzi Arequipa strain (MHOM/Pe/2011/Arequipa) as an interesting model for CD drug discovery. We characterized acute-phase parasitaemia and chronic-phase tropism in BALB/c mice and determined the in vitro and in vivo benznidazole susceptibility profile of the different morphological forms of this strain. The tropism of this strain makes it an interesting model for the screening of new compounds with a potential anti-Chagas profile for the treatment of this disease.

Item Type: Article
DOI/Identification number: 10.1016/j.actatropica.2022.106679
Uncontrolled keywords: Benznidazole, Chemotherapy, Chagas disease, Drug discovery, Trypanosoma cruzi, Arequipa strain
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > Biosciences
SWORD Depositor: JISC Publications Router
Depositing User: JISC Publications Router
Date Deposited: 30 Aug 2024 13:27 UTC
Last Modified: 02 Sep 2024 10:49 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/97108 (The current URI for this page, for reference purposes)

University of Kent Author Information

Martín-Escolano, Rubén.

Creator's ORCID: https://orcid.org/0000-0002-6262-9344
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