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Generalized Prediction of Unconsciousness during Propofol Anesthesia using 3D Convolutional Neural Networks

Patlatzoglou, Konstantinos, Chennu, Srivas, Gosseries, Olivia, Bonhomme, Vincent, Wolff, Audrey, Laureys, Steven (2020) Generalized Prediction of Unconsciousness during Propofol Anesthesia using 3D Convolutional Neural Networks. In: Engineering in Medicine and Biology Society (EMBC), Annual International Conference of the IEEE. 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society. . pp. 134-137. IEEE ISBN 978-1-72811-990-8. (doi:10.1109/EMBC44109.2020.9175324) (KAR id:97094)


Neuroscience has generated a number of recent advances in the search for the neural correlates of consciousness, but these have yet to find valuable real-world applications. Electroencephalography under anesthesia provides a powerful experimental setup to identify electrophysiological signatures of altered states of consciousness, as well as a testbed for developing systems for automatic diagnosis and prognosis of awareness in clinical settings. In this work, we use deep convolutional neural networks to automatically differentiate sub-anesthetic states and depths of anesthesia, solely from one second of raw EEG signal. Our results with leave-one-participant-out-cross-validation show that behavioral measures, such as the Ramsay score, can be used to learn generalizable neural networks that reliably predict levels of unconsciousness in unseen transitional anesthetic states, as well as in unseen experimental setups and behaviors. Our findings highlight the potential of deep learning to detect progressive changes in anesthetic-induced unconsciousness with higher granularity than behavioral or pharmacological markers. This work has broader significance for identifying generalized patterns of brain activity that index states of consciousness.

Item Type: Conference or workshop item (Proceeding)
DOI/Identification number: 10.1109/EMBC44109.2020.9175324
Subjects: R Medicine
T Technology
Divisions: Divisions > Division of Computing, Engineering and Mathematical Sciences > School of Computing
Funders: University of Kent (
Depositing User: Konstantinos Patlatzoglou
Date Deposited: 25 Sep 2022 09:17 UTC
Last Modified: 26 Sep 2022 10:26 UTC
Resource URI: (The current URI for this page, for reference purposes)

University of Kent Author Information

Patlatzoglou, Konstantinos.

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