Doolan, Jack, Williams, George T., Hilton, Kira, Chaudhary, Rajas, Fossey, J. S., Goult, Benjamin T, Hiscock, Jennifer R. (2022) Advancements in antimicrobial nanoscale materials and self-assembling systems. Chemical Society Reviews, 51 . pp. 8696-8755. ISSN 0306-0012. (doi:10.1039/D1CS00915J) (KAR id:96987)
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Official URL: https://doi-org.chain.kent.ac.uk/10.1039/D1CS00915... |
Abstract
Antimicrobial resistance is directly responsible for more deaths per year than either HIV/AIDS or malaria and is predicted to incur a cumulative societal financial burden of at least $100 trillion between 2014 and 2050. Already heralded as one of the greatest threats to human health, the onset of the coronavirus pandemic has accelerated the prevalence of antimicrobial resistant bacterial infections due to factors including increased global antibiotic/antimicrobial use. Thus an urgent need for novel therapeutics to combat what some have termed the ‘silent pandemic’ is evident. This review acts as a repository of research and an overview of the novel therapeutic strategies being developed to overcome antimicrobial resistance, with a focus on self-assembling systems and nanoscale materials. The fundamental mechanisms of action, as well as the key advantages and disadvantages of each system are discussed, and attention is drawn to key examples within each field. As a result, this review provides a guide to the further design and development of antimicrobial systems, and outlines the interdisciplinary techniques required to translate this fundamental research towards the clinic.
Item Type: | Article |
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DOI/Identification number: | 10.1039/D1CS00915J |
Additional information: | For the purpose of open access, the author(s) has applied a Creative Commons Attribution (CC BY) licence to any Author Accepted Manuscript version arising. |
Subjects: |
Q Science Q Science > QD Chemistry |
Divisions: |
Divisions > Division of Natural Sciences > Biosciences Divisions > Division of Natural Sciences > Chemistry and Forensics |
Funders: |
UK Research and Innovation (https://ror.org/001aqnf71)
Biotechnology and Biological Sciences Research Council (https://ror.org/00cwqg982) Cancer Research UK (https://ror.org/054225q67) University of Kent (https://ror.org/00xkeyj56) |
Depositing User: | Jennifer Hiscock |
Date Deposited: | 19 Sep 2022 17:51 UTC |
Last Modified: | 07 Aug 2024 13:09 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/96987 (The current URI for this page, for reference purposes) |
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