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Probing the self-assembly and anti-glioblastoma efficacy of a cinnamoyl-capped dipeptide hydrogelator

Sitsanidis, E. D., Kasapidou, P. M., Hiscock, Jennifer R., Gubala, V., castel, H, Popoola, Precious, Hall, Andrew J., Edwards, Alison A. (2022) Probing the self-assembly and anti-glioblastoma efficacy of a cinnamoyl-capped dipeptide hydrogelator. Organic and Biomolecular Chemistry, 20 (37). pp. 7458-7466. ISSN 1477-0520. (doi:10.1039/D2OB01339H) (KAR id:96699)

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Official URL:
https://doi.org/10.1039/D2OB01339H

Abstract

Herein, we introduce the first diphenylalanine dipeptide hydrogelator capped with the cinnamoyl functional group (Cin-L-F-L-F). We evaluate the effects of the cinnamoyl moiety on molecular self-assembly events and resultant physical properties of the hydrogel formed. In addition, we report our preliminary results of this dipeptide’s cytotoxicity against glioblastoma (GBM) cancer cells.

Item Type: Article
DOI/Identification number: 10.1039/D2OB01339H
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Divisions > Division of Natural Sciences > Chemistry and Forensics
Funders: UK Research and Innovation (https://ror.org/001aqnf71)
Jane and Aatos Erkko Foundation (https://ror.org/03vxy9y38)
University of Kent (https://ror.org/00xkeyj56)
Depositing User: Jennifer Hiscock
Date Deposited: 01 Sep 2022 17:36 UTC
Last Modified: 03 Oct 2022 14:19 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/96699 (The current URI for this page, for reference purposes)
Hiscock, Jennifer R.: https://orcid.org/0000-0002-1406-8802
Gubala, V.: https://orcid.org/0000-0001-6301-3632
Hall, Andrew J.: https://orcid.org/0000-0001-8849-7063
Edwards, Alison A.: https://orcid.org/0000-0002-4637-9373
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