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COVID-19 vaccination and carditis in children and adolescents: a systematic review and meta-analysis

Chou, Oscar Hou In, Mui, Jonathan, Chung, Cheuk To, Radford, Danny, Ranjithkumar, Simon, Evbayekha, Endurance, Nam, Ronald, Pay, Levent, Satti, Danish Iltaf, Garcia-Zamora, Sebastian, and others. (2022) COVID-19 vaccination and carditis in children and adolescents: a systematic review and meta-analysis. Clinical research in cardiology : official journal of the German Cardiac Society, . ISSN 1861-0692. (doi:10.1007/s00392-022-02070-7) (KAR id:96669)


<h4>Background</h4>Coronavirus Disease-2019 (COVID-19) vaccination has been associated with the development of carditis, especially in children and adolescent males. However, the rates of these events in the global setting have not been explored in a systematic manner. The aim of this systematic review and meta-analysis is to investigate the rates of carditis in children and adolescents receiving COVID-19 vaccines.<h4>Methods</h4>PubMed, Embase and several Latin American databases were searched for studies. The number of events, and where available, at-risk populations were extracted. Rate ratios were calculated and expressed as a rate per million doses received. Subgroup analysis based on the dose administered was performed. Subjects ≤ 19 years old who developed pericarditis or myocarditis following COVID-19 vaccination were included.<h4>Results</h4>A total of 369 entries were retrieved. After screening, 39 articles were included. Our meta-analysis found that 343 patients developed carditis after the administration of 12,602,625 COVID-19 vaccination doses (pooled rate per million: 37.76; 95% confidence interval [CI] 23.57, 59.19). The rate of carditis was higher amongst male patients (pooled rate ratio: 5.04; 95% CI 1.40, 18.19) and after the second vaccination dose (pooled rate ratio: 5.60; 95% CI 1.97, 15.89). In 301 cases of carditis (281 male; mean age: 15.90 (standard deviation [SD] 1.52) years old) reported amongst the case series/reports, 261 patients were reported to have received treatment. 97.34% of the patients presented with chest pain. The common findings include ST elevation and T wave abnormalities on electrocardiography. Oedema and late gadolinium enhancement in the myocardium were frequently observed in cardiac magnetic resonance imaging (CMR). The mean length of hospital stay was 3.91 days (SD 1.75). In 298 out of 299 patients (99.67%) the carditis resolved with or without treatment.<h4>Conclusions</h4>Carditis is a rare complication after COVID-19 vaccination across the globe, but the vast majority of episodes are self-limiting with rapid resolution of symptoms within days. Central illustration. Balancing the benefits of vaccines on COVID-19-caused carditis and post-vaccination carditis.

Item Type: Article
DOI/Identification number: 10.1007/s00392-022-02070-7
Additional information: ** From Europe PMC via Jisc Publications Router ** History: ppub 01-07-2022; epub 30-07-2022. ** Licence for this article: cc by
Uncontrolled keywords: Vaccine, Myocarditis, pericarditis, Carditis, Covid-19
Subjects: R Medicine
Divisions: Divisions > Division of Natural Sciences > Kent and Medway Medical School
SWORD Depositor: JISC Publications Router
Depositing User: JISC Publications Router
Date Deposited: 07 Sep 2022 14:52 UTC
Last Modified: 08 Sep 2022 14:18 UTC
Resource URI: (The current URI for this page, for reference purposes)

University of Kent Author Information

Radford, Danny.

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Tse, Gary.

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