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ICIs-Related Cardiotoxicity in Different Types of Cancer

Dong, Mei, Yu, Ting, Zhang, Zhenzhen, Zhang, Jing, Wang, Rujian, Tse, Gary, Liu, Tong, Zhong, Lin (2022) ICIs-Related Cardiotoxicity in Different Types of Cancer. Journal of Cardiovascular Development and Disease, 9 (7). Article Number 203. ISSN 2308-3425. (doi:10.3390/jcdd9070203) (KAR id:96633)


Immune checkpoint inhibitors (ICIs) are rapidly developing immunotherapy cancer drugs that have prolonged patient survival. However, ICIs-related cardiotoxicity has been recognized as a rare, but fatal, consequence. Although there has been extensive research based on different types of ICIs, these studies have not indicated whether cardiotoxicity is specific to a type of cancer. Therefore, we conducted a systematic review to analyze a variety of ICIs-related cardiotoxicity, focusing on different types of cancer. We found that the incidence of ICIs-related cardiac adverse events (CAEs) and common cardiotoxic manifestations vary with cancer type. This inspired us to explore the underlying mechanisms to formulate targeted clinical strategies for maintaining the cardiovascular health of cancer patients.

Item Type: Article
DOI/Identification number: 10.3390/jcdd9070203
Additional information: ** From Europe PMC via Jisc Publications Router ** History: ppub 01-06-2022; epub 28-06-2022. ** Licence for this article: cc by
Uncontrolled keywords: Cardiotoxicity, Cardio-oncology, Immune Checkpoint Inhibitors, Cancer-type-specific
Subjects: R Medicine
Divisions: Divisions > Division of Natural Sciences > Kent and Medway Medical School
Funders: University of Kent (
SWORD Depositor: JISC Publications Router
Depositing User: JISC Publications Router
Date Deposited: 23 Nov 2022 10:14 UTC
Last Modified: 23 Dec 2022 09:28 UTC
Resource URI: (The current URI for this page, for reference purposes)

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