Skip to main content
Kent Academic Repository

Atrial cardiomyopathy: from cell to bedside.

Li, Mengmeng, Ning, Yuye, Tse, Gary, Saguner, Ardan M, Wei, Meng, Day, John D, Luo, Guogang, Li, Guoliang (2022) Atrial cardiomyopathy: from cell to bedside. ESC heart failure, 9 (6). pp. 3768-3784. ISSN 2055-5822. (doi:10.1002/ehf2.14089) (KAR id:96255)


Atrial cardiomyopathy refers to structural and electrical remodelling of the atria, which can lead to impaired mechanical function. While historical studies have implicated atrial fibrillation as the leading cause of cardioembolic stroke, atrial cardiomyopathy may be an important, underestimated contributor. To date, the relationship between atrial cardiomyopathy, atrial fibrillation, and cardioembolic stroke remains obscure. This review summarizes the pathogenesis of atrial cardiomyopathy, with a special focus on neurohormonal and inflammatory mechanisms, as well as the role of adipose tissue, especially epicardial fat in atrial remodelling. It reviews the current evidence implicating atrial cardiomyopathy as a cause of embolic stroke, with atrial fibrillation as a lagging marker of an increased thrombogenic atrial substrate. Finally, it discusses the potential of antithrombotic therapy in embolic stroke with undetermined source and appraises the available diagnostic techniques for atrial cardiomyopathy, including imaging techniques such as echocardiography, computed tomography, and magnetic resonance imaging as well as electroanatomic mapping, electrocardiogram, biomarkers, and genetic testing. More prospective studies are needed to define the relationship between atrial cardiomyopathy, atrial fibrillation, and embolic stroke and to establish a prompt diagnosis and specific treatment strategies in these patients with atrial cardiomyopathy for the secondary and even primary prevention of embolic stroke.

Item Type: Article
DOI/Identification number: 10.1002/ehf2.14089
Additional information: ** From PubMed via Jisc Publications Router ** History: received 01-04-2022; revised 09-06-2022; accepted 10-07-2022.
Uncontrolled keywords: Pathogenesis, Atrial cardiomyopathy, Atrial fibrillation, Embolic stroke, Diagnosis
Subjects: R Medicine
Divisions: Divisions > Division of Natural Sciences > Kent and Medway Medical School
Funders: National Natural Science Foundation of China (
SWORD Depositor: JISC Publications Router
Depositing User: JISC Publications Router
Date Deposited: 23 Nov 2022 12:44 UTC
Last Modified: 04 Mar 2024 18:45 UTC
Resource URI: (The current URI for this page, for reference purposes)

University of Kent Author Information

  • Depositors only (login required):

Total unique views for this document in KAR since July 2020. For more details click on the image.