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Progression of socio-cognitive impairment from healthy aging to Alzheimer’s dementia: A systematic review and meta-analysis

Roheger, Mandy, Brenning, Jana, Riemann, Steffen, Martin, Andrew K., Flöel, Agnes, Meinzer, Marcus (2022) Progression of socio-cognitive impairment from healthy aging to Alzheimer’s dementia: A systematic review and meta-analysis. Neuroscience & Biobehavioral Reviews, 140 . Article Number 104796. ISSN 0149-7634. (doi:10.1016/j.neubiorev.2022.104796) (KAR id:96141)


Background: Trajectories of decline across different socio-cognitive domains in healthy older adults and in pathological aging conditions have not been investigated. This was addressed in the present systematic review and meta-analysis.

Methods: MEDLINE, Web of Science Core Collection, CENTRAL, and PsycInfo were searched for studies investigating social cognition across four domains (Theory of Mind, ToM; emotion recognition, ER; Social-decision making, SD; visual perspective taking, VPT) in healthy older individuals, individuals with subjective and mild cognitive impairment (SCD, MCI) and Alzheimer’s disease (AD). Random-effects meta-analyses were conducted.

Results: Of 8137 screened studies, 132 studies were included in the review. ToM and ER showed a clear progression of impairment from normal aging to AD. Differential patterns of decline were identified for different types of ToM and ER.

Conclusion: This systematic review identified progression of impairment of specific socio-cognitive abilities, which is the necessary pre-requisite for developing targeted interventions. We identified a lack of research on socio-cognitive decline in different populations (e.g., middle age, SCD and MCI-subtypes) and domains (SDM, VPT).

Item Type: Article
DOI/Identification number: 10.1016/j.neubiorev.2022.104796
Uncontrolled keywords: Social cognition, Healthy aging, Subjective cognitive decline, Mild cognitive impairment, Alzheimer’s disease, Theory of mind, Emotion recognition, Meta-analysis
Subjects: R Medicine
Divisions: Divisions > Division of Human and Social Sciences > School of Psychology
Funders: University of Kent (
Depositing User: Andrew Martin
Date Deposited: 09 Aug 2022 11:23 UTC
Last Modified: 25 Jul 2023 23:00 UTC
Resource URI: (The current URI for this page, for reference purposes)

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