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An Updated View of the Trypanosoma cruzi Life Cycle: Intervention Points for an Effective Treatment

Martín-Escolano, Javier, Marín, Clotilde, Rosales, María J., Tsaousis, Anastasios D., Medina-Carmona, Encarnacion, Martín-Escolano, Rubén (2022) An Updated View of the Trypanosoma cruzi Life Cycle: Intervention Points for an Effective Treatment. ACS Infectious Diseases, 8 (6). pp. 1107-1115. ISSN 2373-8227. (doi:10.1021/acsinfecdis.2c00123) (KAR id:96098)

Abstract

Chagas disease (CD) is a parasitic, systemic, chronic, and often fatal illness caused by infection with the protozoan Trypanosoma cruzi. The World Health Organization classifies CD as the most prevalent of poverty-promoting neglected tropical diseases, the most important parasitic one, and the third most infectious disease in Latin America. Currently, CD is a global public health issue that affects 6–8 million people. However, the current approved treatments are limited to two nitroheterocyclic drugs developed more than 50 years ago. Many efforts have been made in recent decades to find new therapies, but our limited understanding of the infection process, pathology development, and long-term nature of this disease has made it impossible to develop new drugs, effective treatment, or vaccines. This Review aims to provide a comprehensive update on our understanding of the current life cycle, new morphological forms, and genetic diversity of T. cruzi, as well as identify intervention points in the life cycle where new drugs and treatments could achieve a parasitic cure.

Item Type: Article
DOI/Identification number: 10.1021/acsinfecdis.2c00123
Uncontrolled keywords: Chagas disease; drug discovery; evolution model; genetic diversity; life cycle; morphological forms; target product profile; tropism; Trypanosoma cruzi
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Ruben Martin Escolano
Date Deposited: 05 Aug 2022 15:06 UTC
Last Modified: 05 Aug 2022 15:13 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/96098 (The current URI for this page, for reference purposes)

University of Kent Author Information

Tsaousis, Anastasios D..

Creator's ORCID: https://orcid.org/0000-0002-5424-1905
CReDIT Contributor Roles:

Martín-Escolano, Rubén.

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