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Amygdalin Exerts Antitumor Activity in Taxane-Resistant Prostate Cancer Cells

Tsaur, Igor, Thomas, Anita, Monecke, Michelle, Zugelder, Marion, Rutz, Jochen, Grein, Timothy, Maxeiner, Sebastian, Xie, Hui, Chun, Felix K.-H., Rothweiler, Florian, and others. (2022) Amygdalin Exerts Antitumor Activity in Taxane-Resistant Prostate Cancer Cells. Cancers, 14 (13). Article Number 3111. E-ISSN 2072-6694. (doi:10.3390/cancers14133111) (KAR id:96001)


Despite recent advances in the treatment of metastatic prostate cancer (PCa), resistance development after taxane treatments is inevitable, necessitating effective options to combat drug resistance. Previous studies indicated antitumoral properties of the natural compound amygdalin. However, whether amygdalin acts on drug-resistant tumor cells remains questionable. An in vitro study was performed to investigate the influence of amygdalin (10 mg/mL) on the growth of a panel of therapy-naïve and docetaxel- or cabazitaxel-resistant PCa cell lines (PC3, DU145, and LNCaP cells). Tumor growth, proliferation, clonal growth, and cell cycle progression were investigated. The cell cycle regulating proteins (phospho)cdk1, (phospho)cdk2, cyclin A, cyclin B, p21, and p27 and the mammalian target of rapamycin (mTOR) pathway proteins (phospho)Akt, (phospho)Raptor, and (phospho)Rictor as well as integrin β1 and the cytoskeletal proteins vimentin, ezrin, talin, and cytokeratin 8/18 were assessed. Furthermore, chemotactic activity and adhesion to extracellular matrix components were analyzed. Amygdalin dose-dependently inhibited tumor growth and reduced tumor clones in all (parental and resistant) PCa cell lines, accompanied by a G0/G1 phase accumulation. Cell cycle regulating proteins were significantly altered by amygdalin. A moderate influence of amygdalin on tumor cell adhesion and chemotaxis was observed as well, paralleled by modifications of cytoskeletal proteins and the integrin β1 expression level. Amygdalin may, therefore, block tumor growth and disseminative characteristics of taxane-resistant PCa cells. Further studies are warranted to determine amygdalin’s value as an antitumor drug.

Item Type: Article
DOI/Identification number: 10.3390/cancers14133111
Uncontrolled keywords: prostate cancer; resistant cell lines; complementary/alternative medicine (CAM); amygdalin; docetaxel; cabozantinib; cabazitaxel
Subjects: R Medicine > RC Internal medicine > RC254 Neoplasms. Tumors. Oncology
R Medicine > RM Therapeutics. Pharmacology
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Martin Michaelis
Date Deposited: 01 Aug 2022 15:05 UTC
Last Modified: 02 Aug 2022 09:01 UTC
Resource URI: (The current URI for this page, for reference purposes)

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