Skip to main content
Kent Academic Repository

Circulating Vitamin D Concentrations and Risk of Atrial Fibrillation: A Mendelian Randomization Study Using Non-deficient Range Summary Statistics

Zhang, Nan, Wang, Yueying, Chen, Ziliang, Liu, Daiqi, Tse, Gary, Korantzopoulos, Panagiotis, Letsas, Konstantinos P, Goudis, Christos A, Lip, Gregory Y H, Li, Guangping, and others. (2022) Circulating Vitamin D Concentrations and Risk of Atrial Fibrillation: A Mendelian Randomization Study Using Non-deficient Range Summary Statistics. Frontiers in Nutrition, 9 . Article Number 842392. ISSN 2296-861X. (doi:10.3389/fnut.2022.842392) (KAR id:95842)


Vitamin D deficiency is a common disorder and has been linked with atrial fibrillation (AF) in several observational studies, although the causal relationships remain unclear. We conducted a Mendelian randomization (MR) analysis to determine the causal association between serum 25-hydroxyvitamin D [25(OH)D] concentrations and AF. The analyses were performed using summary statistics obtained for single-nucleotide polymorphisms (SNPs) identified from large genome-wide association meta-analyses conducted on serum 25(OH)D ( = 79,366) and AF ( = 1,030,836). Six SNPs related to serum 25(OH)D were used as instrumental variables. The association between 25(OH)D and AF was estimated using both the fixed-effect and random-effects inverse variance weighted (IVW) method. The MR analyses found no evidence to support a causal association between circulating 25(OH)D level and risk of AF using random-effects IVW (odds ratio per unit increase in log 25(OH)D = 1.003, 95% CI, 0.841-1.196; = 0.976) or fixed-effect IVW method (OR = 1.003, 95% CI, 0.876-1.148; = 0.968). Sensitivity analyses yielded similar results. No heterogeneity and directional pleiotropy were detected. Using summary statistics, this MR study suggests that genetically predicted circulating vitamin D concentrations, especially for a non-deficient range, were not causally associated with AF in the general population. Future studies using non-linear design and focusing on the vitamin D deficiency population are needed to further evaluate the causal effect of vitamin D concentrations on AF.

Item Type: Article
DOI/Identification number: 10.3389/fnut.2022.842392
Additional information: ** From PubMed via Jisc Publications Router ** History: received 23-12-2021; accepted 13-04-2022.
Uncontrolled keywords: vitamin D, atrial fibrillation, causal association, single-nucleotide polymorphisms, Mendelian randomization
Subjects: R Medicine
Divisions: Divisions > Division of Natural Sciences > Kent and Medway Medical School
Funders: National Natural Science Foundation of China (
SWORD Depositor: JISC Publications Router
Depositing User: JISC Publications Router
Date Deposited: 22 Nov 2022 16:53 UTC
Last Modified: 04 Mar 2024 19:28 UTC
Resource URI: (The current URI for this page, for reference purposes)

University of Kent Author Information

  • Depositors only (login required):

Total unique views for this document in KAR since July 2020. For more details click on the image.