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Human seasonal coronavirus neutralisation and COVID‐19 severity

Wells, David A., Cantoni, Diego, Mayora‐Neto, Martin, Di Genova, Cecilia, Sampson, Alexander, Ferrari, Matteo, Carnell, George, Nadesalingam, Angalee, Smith, Peter, Chan, Andrew, and others. (2022) Human seasonal coronavirus neutralisation and COVID‐19 severity. Journal of Medical Virology, 94 (10). pp. 4820-4829. ISSN 0146-6615. E-ISSN 1096-9071. (doi:10.1002/jmv.27937) (KAR id:95469)

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Abstract

The virus SARS-CoV-2, responsible for the global COVID-19 pandemic, spread rapidly around the world causing high morbidity and mortality. However, there are four known, endemic seasonal coronaviruses in humans (HCoVs) and whether antibodies for these HCoVs play a role in severity of COVID-19 disease has generated a lot of interest. Of these seasonal viruses NL63 is of particular interest as it uses the same cell entry receptor as SARS-CoV-2. We use functional, neutralising assays to investigate cross reactive antibodies and their relationship with COVID-19 severity. We analysed neutralisation of SARS-CoV-2, NL63, HKU1, and 229E in 38 COVID-19 patients and 62 healthcare workers, and a further 182 samples to specifically study the relationship between SARS-CoV-2 and NL63.We found that although HCoV neutralisation was very common there was little evidence that these antibodies neutralised SARS-CoV-2. Despite no evidence in cross neutralisation, levels of NL63 neutralising antibodies become elevated after exposure to SARS-CoV-2 through infection or following vaccination.

Item Type: Article
DOI/Identification number: 10.1002/jmv.27937
Uncontrolled keywords: endemic infection, epidemiology, neutralization, immune responses, SARS coronavirus, virus classification
Subjects: Q Science > QR Microbiology > QR355 Virology
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User: Nigel Temperton
Date Deposited: 16 Jun 2022 10:36 UTC
Last Modified: 24 Aug 2022 12:37 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/95469 (The current URI for this page, for reference purposes)
Temperton, Nigel J.: https://orcid.org/0000-0002-7978-3815
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