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Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure

Reynolds, Catherine J., Pade, Corinna, Gibbons, Joseph M., Otter, Ashley D., Lin, Kai-Min, Muñoz Sandoval, Diana, Pieper, Franziska P., Butler, David K., Liu, Siyi, Joy, George, and others. (2022) Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure. Science, . ISSN 0036-8075. (doi:10.1126/science.abq1841) (KAR id:95432)

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Official URL:
https://doi.org/10.1126/science.abq1841

Abstract

The Omicron, or Pango lineage B.1.1.529, variant of SARS-CoV-2 carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show protection from severe disease, often attributed to primed cellular immunity. We investigated T and B cell immunity against B.1.1.529 in triple mRNA vaccinated healthcare workers (HCW) with different SARS-CoV-2 infection histories. B and T cell immunity against previous variants of concern was enhanced in triple vaccinated individuals, but magnitude of T and B cell responses against B.1.1.529 spike protein was reduced. Immune imprinting by infection with the earlier B.1.1.7 (Alpha) variant resulted in less durable binding antibody against B.1.1.529. Previously infection-naïve HCW who became infected during the B.1.1.529 wave showed enhanced immunity against earlier variants, but reduced nAb potency and T cell responses against B.1.1.529 itself. Previous Wuhan Hu-1 infection abrogated T cell recognition and any enhanced cross-reactive neutralizing immunity on infection with B.1.1.529.

Item Type: Article
DOI/Identification number: 10.1126/science.abq1841
Uncontrolled keywords: Covid-19, SARS-CoV-2, Omicron
Subjects: Q Science > QR Microbiology > QR355 Virology
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User: Nigel Temperton
Date Deposited: 14 Jun 2022 20:29 UTC
Last Modified: 15 Jun 2022 09:26 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/95432 (The current URI for this page, for reference purposes)
Temperton, Nigel J.: https://orcid.org/0000-0002-7978-3815
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