The Azinomycins, Discovery, Synthesis and DNA binding Studies

Casely-Hayford, Maxwell A. and Searcey, Mark (2003) The Azinomycins, Discovery, Synthesis and DNA binding Studies. In: Demeunynck, Martine and Bailly, Christian and Wilson, David W., eds. Small Molecule DNA and RNA Binders: From Small Molecules to Drugs. Wiley-VCH, pp. 676-696. ISBN 3527305955. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Nature is a rich source of antitumour agents that can act as a paradigm for the development of synthetic agents that retain the biological activity of the natural product but are targeted to the tumor, have increased bioavailability or are simply prodrug forms that are inactive until administered. Examples of potent antitumour antibiotics that interact with DNA include CC-1065 and the duocarmycins, ecteinascidin 743 and rebeccamycin. The azinomycins A (1) and B (2) (Fig. 24.1) and the truncated analogue 3 represent novel structures that have been extensively explored from a synthetic viewpoint, bot for which studies of structure-activity relationships from a DNA binding and biological viewpoint have been few and widely spaced chronologically. In this chapter we aim to bring together the details of the isolation, synthesis, structural, and DNA-binding studies of the azinomycins, to generate a starting point from which to begin to understand the properties of these natural products that could lead to new, therapeutically relevant compounds.

Item Type: Book section
Subjects: Q Science > QD Chemistry
Divisions: Faculties > Science Technology and Medical Studies > Medway School of Pharmacy
Depositing User: Maxwell Casely-Hayford
Date Deposited: 09 Sep 2008 09:35
Last Modified: 14 Jan 2010 14:35
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