Stereoselectivity, sequence specificity and mechanism of action of the azinomycin epoxide.

David-Cordonnier, Marie-Helene, Casely-Hayford, Maxwell A., Kouach, Mostafa, Briand, Gilbert, Patterson, Laurence H., Bailly, Christian, Searcey, Mark (2006) Stereoselectivity, sequence specificity and mechanism of action of the azinomycin epoxide. ChemBioChem, 7 (11). pp. 1658-1661. (doi:10.1002/cbic.200600244) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

Abstract

In this study we show that the four diastereomers of the azinomycin epoxide (1) have different sequence selectivities, while the natural product appears to exert its effects through reversible N7 alkylation of guanine followed by irreversible depurination (see scheme).

Item Type:	Article
DOI/Identification number:	10.1002/cbic.200600244
Projects:	[53] Study of the mechanism of action of the azinomycin epoxide
Uncontrolled keywords:	antitumor agents, azinomycin, depurination, DNA cleavage, natural products
Subjects:	Q Science
Divisions:	Faculties > Sciences > Medway School of Pharmacy
Depositing User:	Maxwell Casely-Hayford
Date Deposited:	23 Sep 2008 14:32 UTC
Last Modified:	28 May 2019 13:45 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/9475 (The current URI for this page, for reference purposes)