Stereoselectivity, sequence specificity and mechanism of action of the azinomycin epoxide.

David-Cordonnier, Marie-Helene and Casely-Hayford, Maxwell A. and Kouach, Mostafa and Briand, Gilbert and Patterson, Laurence H. and Bailly, Christian and Searcey, Mark (2006) Stereoselectivity, sequence specificity and mechanism of action of the azinomycin epoxide. ChemBioChem, 7 (11). pp. 1658-1661. (doi:10.1002/cbic.200600244) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Official URL http://dx.doi.org/10.1002/cbic.200600244

Abstract

In this study we show that the four diastereomers of the azinomycin epoxide (1) have different sequence selectivities, while the natural product appears to exert its effects through reversible N7 alkylation of guanine followed by irreversible depurination (see scheme).

Item Type:	Article
Projects:	[53] Study of the mechanism of action of the azinomycin epoxide
Uncontrolled keywords:	antitumor agents, azinomycin, depurination, DNA cleavage, natural products
Subjects:	Q Science
Divisions:	Faculties > Science Technology and Medical Studies > Medway School of Pharmacy
Depositing User:	Maxwell Casely-Hayford
Date Deposited:	23 Sep 2008 14:32
Last Modified:	14 Jan 2010 14:35
Resource URI:	https://kar.kent.ac.uk/id/eprint/9475 (The current URI for this page, for reference purposes)