David-Cordonnier, Marie-Helene, Casely-Hayford, Maxwell A., Kouach, Mostafa, Briand, Gilbert, Patterson, Laurence H., Bailly, Christian, Searcey, Mark (2006) Stereoselectivity, sequence specificity and mechanism of action of the azinomycin epoxide. ChemBioChem, 7 (11). pp. 1658-1661. (doi:10.1002/cbic.200600244) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:9475)
| The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication) | |
| Official URL http://dx.doi.org/10.1002/cbic.200600244 |
Abstract
In this study we show that the four diastereomers of the azinomycin epoxide (1) have different sequence selectivities, while the natural product appears to exert its effects through reversible N7 alkylation of guanine followed by irreversible depurination (see scheme).
| Item Type: | Article |
|---|---|
| DOI/Identification number: | 10.1002/cbic.200600244 |
| Projects: | [53] Study of the mechanism of action of the azinomycin epoxide |
| Uncontrolled keywords: | antitumor agents, azinomycin, depurination, DNA cleavage, natural products |
| Subjects: | Q Science |
| Divisions: | Faculties > Sciences > Medway School of Pharmacy |
| Depositing User: | Maxwell Casely-Hayford |
| Date Deposited: | 23 Sep 2008 14:32 UTC |
| Last Modified: | 06 May 2020 03:02 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/9475 (The current URI for this page, for reference purposes) |
| Casely-Hayford, Maxwell A.: |  https://orcid.org/0000-0003-4054-4371 |
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